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A Novel Immunomodulatory Hemocyanin from the Limpet Fissurella latimarginata Promotes Potent Anti- Tumor Activity in Melanoma
(PLOS One, 2014)
Hemocyanins, the huge oxygen-transporting glycoproteins of some mollusks, are used as immunomodulatory proteins with
proven anti-cancer properties. The biodiversity of hemocyanins has promoted interest in identifying new ...
Anti-tumor necrosis factor-α therapy augments dipeptidyl peptidase IV activity and decreases autoantibodies to GRP78/BIP and phosphoglucose isomerase in patients with rheumatoid arthritis
(2005)
Objective. To assess the enzymatic activity and biochemical status of dipeptidyl peptidase IV (DPP IV), an enzyme that participates in the degradation of proinflammatory molecules, in sera from a group of patients with ...
Curcumin requires tumor necrosis Factor α signaling to alleviate cognitive impairment elicited by Lipopolysaccharide
(KargerBasel, 2013)
A decline in cognitive ability is a typical feature of the normal aging process, and of neurodegenerative disorders such as Alzheimer’s, Parkinson’s and Huntington’s diseases. Although their etiologies differ, all of these ...
Tuberculosis in the era of anti-TNF-alpha therapy : Why does the risk still exist?
(2018)
Rheumatoid arthritis is an autoimmune systemic disease characterized mainly by inflammatory compromise of diarthrodial joints. Multiple drug therapies have been developed to control the activity of rheumatoid arthritis, ...
Proteomics Approach of Rapamycin Anti-Tumoral Effect on Primary and Metastatic Canine Mammary Tumor Cells In Vitro
(2021-02-25)
Rapamycin is an antifungal drug with antitumor activity and acts inhibiting the mTOR complex. Due to drug antitumor potential, the aim of this study was to evaluate its effect on a preclinical model of primary mammary gland ...
Tumor-induced neurogenesis and immune evasion as targets of innovative anti-cancer therapies
(Nature, 2020-06-18)
Normal cells are hijacked by cancer cells forming together heterogeneous tumor masses immersed in aberrant communication circuits that facilitate tumor growth and dissemination. Besides the well characterized angiogenic ...
Searching for gallium bioactive compounds: Gallium(III) complexes of tridentate salicylaldehyde semicarbazone derivatives
(Pergamon-Elsevier B.V. Ltd, 2014)
Galectins: Key players in the tumor microenvironment
(Elsevier, 2013)
Galectins are glycan‐binding proteins implicated in several biological activities such as intracellular signaling, cell‐cell communication, cellular proliferation and survival. These endogenous lectins have emerged as key ...
CD4+, CD8+, FoxP3+ and HSP60+ Expressions in Cellular Infiltrate of Canine Mammary Carcinoma in Mixed Tumor
(Universidade Federal do Rio Grande do Sul, 2017)