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New perspectives in signaling mediated by receptors coupled to stimulatory G protein: the emerging significance of cAMP efflux and extracellular cAMP-adenosine pathway
(Frontiers Research Foundation, 2015-03-25)
G protein coupled receptors (GPCRs) linked to stimulatory G (Gs) proteins (GsPCRs) mediate increases in intracellular cyclic AMP as consequence of activation of nine adenylyl cyclases, which differ considerably in their ...
Soybean diet improves insulin secretion through activation of cAMP/PKA pathway in rats
(Elsevier Science IncNew YorkEUA, 2008)
Adrenocorticotropin induces mitogen-activated protein kinase phosphatase 1 in Y1 mouse adrenocortical tumor cells
(Endocrine Society, 2003-04)
ACTH signaling pathway includes the action of both protein kinases, mainly cAMP-dependent protein kinase (protein kinase A, PKA), and serine/threonine and tyrosine phosphatases. MAPK phosphatase-1 (MKP-1) is a dual activity ...
The cAMP Signaling pathway and direct protein kinase a phosphorylation regulate polycystin-2 (TRPP2) Channel Function
(American Society for Biochemistry and Molecular Biology, 2015-09)
Polycystin-2 (PC2) is aTRP-type, Ca2+-permeable non-selective cation channel that plays an important role in Ca2+ signaling in renal and non-renal cells. The effect(s) of the cAMP pathway and kinase mediated phosphorylation ...
Effect of bitter compounds on amylase secretion in murine submandibular glands: Signaling pathway mechanisms
(Elsevier Science, 2011-12)
Background: Amylase is synthesized in submandibular glands (SMG) and released into the oral cavity to degrade carbohydrates in the mouth. Bitter taste receptors (T2R) belong to the G-protein coupled receptor (GPCR) family ...
Guanosine promotes B16F10 melanoma cell differentiation through PKC-ERK 1/2 pathway
(ELSEVIER IRELAND LTD, 2008)
Malignant melanoma is one of the most lethal cancers. Nowadays, several anti-melanoma therapies have been employed. However, the poor prognosis and/or the increased toxicity of those treatments clearly demonstrate the ...
CHANGES IN CYCLIC-AMP-DEPENDENT PROTEIN-KINASE AND ACTIVE STIFFNESS IN THE RAT VOLUME OVERLOAD MODEL OF HEART HYPERTROPHY
(ELSEVIER SCIENCE BV, 1993)
Objective: The aim was to clarify the role of cyclic AMP dependent protein kinase (PKA) and changes in mechanical heart function during development of cardiac hypertrophy induced by volume overload. Methods: Protein and ...
Melatonin triggers PKA activation in the rodent malaria parasite Plasmodium chabaudi
(WILEY-BLACKWELL PUBLISHING, INC, 2011)
Calcium (Ca2+) is a critical regulator of many aspects of the Plasmodium reproductive cycle. In particular, intra-erythrocyte Plasmodium parasites respond to circulating levels of the melatonin in a process mediated partly ...