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Insulin therapy and foetoplacental endothelial dysfunction in gestational diabetes mellitus
(2018)
Abstract: Most of women with a diagnose of gestational diabetes mellitus (GDM), a disease
characterised by glucose intolerance and first diagnosed in pregnancy, are subjected to a
controlled diet (GDMd) aiming to reach ...
Maternal Dyslipidaemia in Pregnancy with Gestational Diabetes Mellitus: Possible Impact on Foetoplacental Vascular Function and Lipoproteins in the Neonatal Circulation
(2019)
Dyslipidaemia occurs in pregnancy to secure foetal development. The mother shows a physiological increase in plasma total cholesterol and Triglycerides (TG) as pregnancy progresses (i.e. maternal physiological dyslipidaemia ...
Magnesium salts as therapeutic approach in preeclampsia.
(2015)
Preeclampsia is a heterogeneous pregnancy-specific syndrome
associated with abnormal trophoblast invasion and endothelial
dysfunction. Magnesium (Mg2+) level is decreased in women with
preeclampsia. The use of Mg2+ ...
Tracking nitroxyl-derived posttranslational modifications of phospholamban in cardiac myocytes
(Rockefeller University Press, 2019-04-22)
Cardiovascular disease is the leading cause of morbidity and mortality worldwide. Calcium (Ca2+) mishandling is one of the most striking abnormalities in this wide spectrum of pathologies, among which heart failure (HF) ...
Impact of high glucose and AGEs on cultured kidney-derived cells. Effects on cell viability, lysosomal enzymes and effectors of cell signaling pathways
(Elsevier France-Editions Scientifiques Medicales Elsevier, 2017)
We have previously reported decreased expression and activities of lysosomal cathepsins B and L in diabetic kidney. Relevant morphological changes were observed in proximal tubules, suggesting that these cells are implicated ...
Rise in endothelium-derived NO after stimulation of rat perivascular sympathetic mesenteric nerves
(AMER PHYSIOLOGICAL SOC, 1999-09)
To evaluate whether sympathetic activity induces nitric oxide (NO) production, we perfused the rat arterial mesenteric bed and measured luminally accessible norepinephrine (NE), NO, and cGMP before, during, and after ...