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Improvement of endothelial function by Gunnera tinctoria extract with antioxidant properties
(BioMed Central Ltd, 2020-12)
Background: Gunnera tinctoria has been collected by Mapuche-Pewenche people for food and medicinal purposes. The high polyphenol content of methanolic extract from G. tinctoria leaves with chemical constituents such as ...
5-Lipoxygenase Deficiency Impairs Innate and Adaptive Immune Responses during Fungal Infection
(Public Library Science, 2012-03-20)
5-lipoxygenase-derived products have been implicated in both the inhibition and promotion of chronic infection. Here, we sought to investigate the roles of endogenous 5-lipoxygenase products and exogenous leukotrienes ...
5-Lipoxygenase Deficiency Impairs Innate and Adaptive Immune Responses during Fungal Infection
(Public Library Science, 2012-03-20)
5-lipoxygenase-derived products have been implicated in both the inhibition and promotion of chronic infection. Here, we sought to investigate the roles of endogenous 5-lipoxygenase products and exogenous leukotrienes ...
Exogenous interleukin-33 targets myeloid-derived suppressor cells and generates periphery-induced Foxp3+ regulatory T cells in skin-transplanted mice
(Blackwell Publishing Ltd, 2015)
© 2015 John Wiley & Sons Ltd. Interleukin-33 (IL-33) has been a focus of study because of its variety of functions shaping CD4+ T-cell biology. In the present work, we evaluated the modulatory effect of IL-33 on suppressor ...
Design, Synthesis, and Pharmacological Evaluation of Novel Hybrid Compounds to Treat Sickle Cell Disease Symptoms. Part II: Furoxan Derivatives
(Amer Chemical Soc, 2012-09-13)
Phthalimide derivatives containing furoxanyl subunits as nitric oxide (NO)-donors (3a-g) were designed, synthesized, and evaluated in vitro and in vivo for their potential uses in the oral treatment of sickle cell disease ...
Design, Synthesis, and Pharmacological Evaluation of Novel Hybrid Compounds to Treat Sickle Cell Disease Symptoms. Part II: Furoxan Derivatives
(Amer Chemical Soc, 2012-09-13)
Phthalimide derivatives containing furoxanyl subunits as nitric oxide (NO)-donors (3a-g) were designed, synthesized, and evaluated in vitro and in vivo for their potential uses in the oral treatment of sickle cell disease ...
Synthesis, antiplatelet and antithrombotic activities of resveratrol derivatives with NO-donor properties
(2017-01-01)
Resveratrol (RVT) is a stilbene with a protective effect on the cardiovascular system; however, drawbacks including low bioavailability and fast metabolism limit its efficacy. In this work we described new resveratrol ...
Dieta hiperlipídica induz alterações funcionais, estruturais e mecânicas em artérias de resistência de rato : efeito do tratamento com antagonista do receptor AT₁
(Universidade Federal de PernambucoUFPEBrasilPrograma de Pos Graduacao em Bioquimica e Fisiologia, 2019)
Avaliação do perfil antioxidante de extratos aquoso e etanólico de Phyllanthus niruri IN VITROEvaluation of the antioxidant profile of aqueous and ethanolic extracts of Phyllanthus niruri IN VITRO
(Universidade Federal do PampaCampus Uruguaiana, 2016)
(+)-Altholactone exhibits broad spectrum immune modulating activity by inhibiting the activation of pro-inflammatory cytokines in RAW 264.7 cell lines
(Pergamon-elsevier Science LtdOxfordInglaterra, 2013)