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Nitrosative stress drives heart failure with preserved ejection fraction
(Nature Publishing Group, 2019)
Heart failure with preserved ejection fraction (HFpEF) is a common syndrome with high morbidity and mortality for which there are no evidence-based therapies. Here we report that concomitant metabolic and hypertensive ...
Caveolin-1-Mediated Tumor Suppression Is Linked to Reduced HIF1 alpha S-Nitrosylation and Transcriptional Activity in Hypoxia
(MDPI, 2020)
Caveolin-1 (CAV1) is a well-established nitric oxide synthase inhibitor, whose function as a tumor suppressor is favored by, but not entirely dependent on, the presence of E-cadherin. Tumors are frequently hypoxic and the ...
Neosaxitoxin inhibits the expression of inflammation markers of the M1 Phenotype in macrophages
(MDPI, 2020)
Background: Neosaxitoxin (NeoSTX) has been used as a local anesthetic, but its anti-inflammatory effects have not been well defined. In the present study, we investigate the effects of NeoSTX on lipopolysaccharide ...
Deposition of carbon nanotubes onto aramid fibers using as-received and chemically modified fibers
(Elsevier, 2016)
Multiwall carbon nanotubes (MWCNTs) oxidized by an acid treatment were deposited on the surface of as-received commercial aramid fibers containing a surface coating ("sizing"), and fibers modified by either a chlorosulfonic ...
Differential regulation of collagen secretion by kinin receptors in cardiac fibroblast and myofibroblast
(2012)
Kinins mediate their cellular effects through B1 (B1R) and B2 (B2R) receptors, and the activation of B2R reduces collagen synthesis in cardiac fibroblasts (CF). However, the question of whether B1R and/or B2R have a role ...
Efeito in vitro do haloperidol e risperidona na ativação inflamatória de macrófagos RAW 264.7
(Universidade Federal de Santa MariaBrasilFarmacologiaUFSMPrograma de Pós-Graduação em FarmacologiaCentro de Ciências da Saúde, 2015-04-10)
Introduction: Antipsychotic drugs, such as haloperidol (typical) and risperidone (atypical)
increase the risk of obesity and other endocrine disturbs in psychiatric patients when used in
long term treatments. There is ...
The role of HDL and phospholipids in endothelial cellular senescence
(Instituto Tecnológico y de Estudios Superiores de Monterrey, 2021-05-26)
High-density lipoproteins (HDLs) are commonly recognized as antiatherogenic molecules; these possess anti-inflammatory properties and participate in the production of Nitric Oxide (NO) by endothelial cells. In addition, ...