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Mostrando ítems 41-50 de 564
The Alz-tau Biomarker for Alzheimer's Disease: Study in a Caucasian Population
(IOS Press, 2019)
The establishment of a molecular biomarker for early detection of Alzheimer's disease (AD) is critical for diagnosis and follow up of patients, and as a quantitative parameter in the evaluation of potential new drugs to ...
Pathway to Tau Modifications and the Origins of Alzheimer's Disease
(Elsevier Inc., 2018)
Effect of the microtubule-associated protein tau on dynamics of single-headed motor proteins KIF1A
(American Physical Society, 2014-02)
Intracellular transport based on molecular motors and its regulation are crucial to the functioning of cells. Filamentary tracks of the cells are abundantly decorated with nonmotile microtubule-associated proteins, such ...
Role of Tau Protein in Neuronal Damage in Alzheimer's Disease and Down Syndrome
(Elsevier, 2012)
Neurodegenerative disorders constitute a growing concern worldwide. Their incidence
has increased steadily, in particular among the elderly, a high-risk population that is
becoming an important segment of society. ...
Papel da proteína Tau na fisiopatologia da demência frontotemporal
(Faculdade de Medicina da Universidade de São Paulo, 2009)
CONTEXTO: Sob a denominação demência frontotemporal (DFT) enquadram-se importantes síndromes demenciais de natureza degenerativa progressiva que acometem os lobos frontais e temporais em ambos os hemisférios. As DFTs podem ...
Selective interaction of lansoprazole and Astemizole with tau polymers: Potential new clinical use in diagnosis of Alzheimer's disease
(IOS Press, 2010)
We describe the interactions of two benzimidazole derivatives, astemizole (AST) and lansoprazole (LNS), with anomalous aggregates of tau protein (neurofibrillary tangles). Interestingly, these compounds, with important ...
Modulación de isoformas de la proteína asociada a microtúbulos TAU: rescate de fenotipos moleculares y funcionales en un modelo murino de taupatíaModulation of microtubule associated protein tau isoforms: rescue of functional and molecular phenotypes in a mouse model of tauopathy
(2019-03-07)
Las enfermedades neurodegenerativas pueden ser causadas por una miríada de factores que conllevan a la muerte y/o disfunción de determinadas neuronas del cerebro humano. La enfermedad de Alzheimer (EA) y otras demencias ...
Anomalously phosphorylated tau and Aβ fragments in the CSF correlates with cognitive impairment in MCI subjects
(2006)
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by the presence of extracellular amyloid deposits, consisting largely of Aβ peptide and the presence of intraneuronal aggregates of neurofibillary ...
Genetic ablation of tau improves mitochondrial function and cognitive abilities in the hippocampus
(2018-09)
Tau is a key protein for microtubule stability; however, post-translationally modified tau contributes to neurodegenerative diseases by forming tau aggregates in the neurons. Previous reports from our group and others have ...