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Antimicrobial effect of oligomeric copper(ii) derivatives of bis(pyrimidin-2-ylthio)- and bis(4,6-dimethylpyrimidin-2 ylthio)alkanes
(Revista de Engenharia Química e Química, 2017)
1,3,4-oxadiazóis: estratégias para síntese e derivatização a partir do ácido 4-oxopentanóico
(Universidade Federal de Santa MariaBrasilQuímicaUFSMPrograma de Pós-Graduação em QuímicaCentro de Ciências Naturais e Exatas, 2014-12-19)
This study shows strategies to prepare 1,3,4-oxadiazoles and derivatives from 4-oxopentanoic acid is reported. The compounds 4-(2-(5-substituted-1,3,4-oxadiazol-2-yl)ethyl)-2-(methylthio/phenyl)-6-(trifluoromethyl)pyrimidine; ...
Síntese de compostos contendo núcleos de pirimidínicos derivados de β-enaminodicetonas
(Universidade Federal de Santa MariaBrasilQuímicaUFSMPrograma de Pós-Graduação em QuímicaCentro de Ciências Naturais e Exatas, 2019-03-22)
In this work the reactivity of β-enaminodiketones [RC(O)C(=CHNMe2)C(O)R1], (wher R= C6H5, 4-Me-C6H4, 4-OMe-C6H4, 4-Cl-C6H4 4-NO2-C6H4, thien-2-yl and furan-2-yl) and R1 (CF3 and CO2Et), was studied with dinucleophiles such ...
UMP kinase from Mycobacterium tuberculosis: Mode of action and allosteric interactions, and their likely role in pyrimidine metabolism regulation
(2011-01-15)
The pyrH-encoded uridine 5′-monophosphate kinase (UMPK) is involved in both de novo and salvage synthesis of DNA and RNA precursors. Here we describe Mycobacterium tuberculosis UMPK (MtUMPK) cloning and expression in ...
Modelagem molecular de derivados pirimidínicos e estudos de docking nas enzimas ciclooxigenase 1 e ciclooxigenase 2
(Universidade Federal de São CarlosBRUFSCarPrograma de Pós-Graduação em Biotecnologia - PPGBiotec, 2010-11-23)
In this research molecular docking was used to study enzime-ligand complexes of Cyclooxygenase 1 (COX-1) and Cyclooxygenase 2 (COX-2) with pyrimidine derivatives, aiming at understanding the possible mechanisms of action ...