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Cross‐talk between monocyte invasion and astrocyte proliferation regulates scarring in brain injury
(Nature Publishing Group, 2018-05)
Scar formation after brain injury is still poorly understood. To further elucidate such processes, here, we examine the interplay between astrocyte proliferation taking place predominantly at the vascular interface and ...
Bordetella pertussis iron regulated proteins as potential vaccine components
(Elsevier, 2013-05-31)
Bordetella pertussis is the etiologic agent of whooping cough, an illness whose incidence has been increasing over the last decades. Pertussis reemergence despite high vaccination coverage, together with the recent isolation ...
Three-finger toxins from the venom of Micrurus tschudii (desert coral snake): isolation and characterization of tschuditoxin-I
(2019)
Venoms from Micrurus (New World coral snakes) display potent peripheral neurotoxicity which may cause death
by respiratory paralysis, yet many are poorly or not characterized. The major venom components of coral snakes
are ...
A Systematic, Unbiased Mapping of CD8+ and CD4+ T Cell Epitopes in Yellow Fever Vaccinees
(Frontiers Media S.A., 2020-08)
Examining CD8+ and CD4+ T cell responses after primary Yellow Fever vaccination in a cohort of 210 volunteers, we have identified and tetramer-validated 92 CD8+ and 50 CD4+ T cell epitopes, many inducing strong and prevalent ...
Análisis topológico del interactoma de Helicobacter pylori revela proteínas topológicamente esenciales: identificación de blancos terapéuticos
(2014-01)
La Helicobacter pylori ha colonizado la mitad de la población mundial; su infección presenta una prevalencia
del 70% al 90% en países en vía de desarrollo y del 25% al 50% en países industrializados. Está establecido
que ...
NNAlign-MA; MHC peptidome deconvolution for accurate MHC binding motif characterization and improved t-cell epitope predictions
(American Society for Biochemistry and Molecular Biology, 2019-10)
The set of peptides presented on a cell´s surface by MHC molecules is known as the immunopeptidome. Current mass spectrometry technologies allow for identification of large peptidomes, and studies have proven these data ...
Improved Prediction of MHC II Antigen Presentation through Integration and Motif Deconvolution of Mass Spectrometry MHC Eluted Ligand Data
(American Chemical Society, 2020-06)
Major histocompatibility complex II (MHC II) molecules play a vital role in the onset and control of cellular immunity. In a highly selective process, MHC II presents peptides derived from exogenous antigens on the surface ...
Predição de uma vacina multi-epítopo contra o vírus da febre amarela através de ferramentas de imunoinformática e modelagem molecular
(Universidade Federal do Rio Grande do NorteBrasilUFRNBiomedicinaDepartamento de Biofísica e Farmacologia, 2022-02-14)
Outbreaks of Yellow Fever are observed periodically, especially in endemic regions. However, in 2016, two related outbreaks of urban yellow fever (Luanda/Angola and Kinshasa/Democratic Republic of Congo) exported cases to ...
Three-finger toxins from the venom of Micrurus tschudii tschudii (desert coral snake): Isolation and characterization of tschuditoxin-I.
(Elsevier, 2019)
Venoms from Micrurus (New World coral snakes) display potent peripheral neurotoxicity which may cause death by respiratory paralysis, yet many are poorly or not characterized. The major venom components of coral snakes are ...