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Ca2+-dependent K+ channels from rat olfactory cilia characterized in planar lipid bilayers
(ELSEVIER SCIENCE BV, 2005-03-14)
Olfactory cilia contain cyclic nucleotide-gated and Ca2+-dependent Cl- conductances that underlie excitatory chemotransduction, and a Ca2+-dependent K+ (K-Ca) conductance, apparently involved in inhibitory transduction. ...
Periodic perturbations in Shaker K+ channel gating kinetics by deletions in the S3-S4 linker
(NATL ACAD SCIENCES, 2001-08-14)
Upon depolarization positive charges contained in the transmembrane segment S4 of voltage-dependent channels are displaced from the cytoplasmic to the external milieu, This charge movement leads to channel opening. In ...
Role of the S4 segment in a voltage-dependent calcium-sensitive potassium (hSlo) channel
(AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, 1998-12-04)
We investigated the role of individual charged residues of the S4 region of a MaxiK channel (hSlo) in channel gating, We measured macroscopic currents induced by wild type (WT) and point mutants of hSlo in inside-out ...
Warifteine, a bisbenzylisoquinoline alkaloid, induces relaxation by activating potassium channels in vascular myocytes
(Clinical and Experimental Pharmacology and Physiology, 2013)
External copper inhibits the activity of the large-conductance calcium- and voltage-sensitive potassium channel from skeletal muscle
(2003)
We have characterized the effect of external
copper on the gating properties of the large-conductance calcium- and voltage-sensitive potassium channel from skeletal muscle, incorporated into artificial
bilayers. The ...
Dissection of K+ currents in Caenorhabditis elegans muscle cells by genetics and RNA interference
(NATL ACAD SCIENCES, 2003-11-25)
GFP-promoter experiments have previously shown that at least nine genes encoding potassium channel subunits are expressed in Caenorhabditis elegans muscle. By using genetic, RNA interference, and physiological techniques ...
Hypotensive activity of Campomanesia xanthocarpa leaf extract: beyond angiotensin II type 1 receptor blockage
(Taylor & Francis Ltd, 2020-02-20)
The ability of Campomanesia xanthocarpa leaf extract (CXLE) to alter blood pressure and heart rate was evaluated in anesthetized rats. The CXLE-induced hypotension was evaluated before and after losartan, methylatropine, ...