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Increased Hippocampal Expression of the Divalent Metal Transporter 1 (DMT1) mRNA Variants 1B and +IRE and DMT1 Protein After NMDA-Receptor Stimulation or Spatial Memory Training
(Springer, 2009-08-05)
Iron is essential for crucial neuronal functions
but is also highly toxic in excess. Neurons acquire iron
through transferrin receptor-mediated endocytosis and via
the divalent metal transporter 1 (DMT1). The N-terminus
(1A, ...
Long-Term Effects of Anterior Thalamic Nucleus Deep Brain Stimulation on Spatial Learning in the Pilocarpine Model of Temporal Lobe Epilepsy
(Wiley, 2018)
Introduction and ObjectivesCognitive impairment is a significant comorbidity of temporal lobe epilepsy that is associated with extensive hippocampal cell loss. Deep brain stimulation (DBS) of the anterior thalamic nucleus ...
B-Raf and CRHR1 internalization mediate biphasic ERK1/2 activation by CRH in hippocampal HT22 Cells.
(Endocrine Soc, 2013-03)
CRH is a key regulator of neuroendocrine, autonomic, and behavioral response to stress. CRH-stimulated CRH receptor 1 (CRHR1) activates ERK1/2 depending on intracellular context. In a previous work, we demonstrated that ...
Sulforaphane is anticonvulsant and improves mitochondrial function
(Wiley & Sons, 2015)
The nuclear factor erythroid 2-related factor 2 pathway (Nrf2) has been previously identified to
protect the brain against various impacts. Here, we investigated the effect of the Nrf2 activator
sulforaphane in various ...
Adaptive changes in the rat hippocampal glutamatergic neurotransmission are observed during long-term treatment with lorazepam
(Springer, 2003-12)
Rationale: Chronic treatment with benzodiazepines induces tolerance to most of their pharmacological effects. The best-studied neurochemical correlation to this phenomenon involves GABAergic adaptive changes. However, some ...