Buscar
Mostrando ítems 41-50 de 84
The cAMP effectors, Rap2b and EPAC, are involved in the regulation of the development of the Coxiella burnetii containing vacuole by altering the fusogenic capacity of the vacuole
(Public Library of Science, 2019-02)
Cyclic Adenosine 3 0 ,5 0 -monophosphate (cAMP) is a key second messenger known to directly regulate not only the protein kinase A (PKA) activity but also other important molecules such as the exchange protein activated ...
Caracterização funcional da região promotora do gene Rasgef1b e avaliação de componentes da via de sinalização de receptores do tipo toll (TLRs) sobre sua regulação
(Universidade Federal de Minas GeraisBrasilICB - INSTITUTO DE CIÊNCIAS BIOLOGICASPrograma de Pós-Graduação em Biologia CelularUFMG, 2016-02-19)
The guanine nucleotide exchange factor RasGEF1b is encoded by a gene whose
expression is induced in innate immune cells in response to the activation of Toll-like
receptors (TLRs). RasGEF1b mRNA levels are increased in ...
The salivary peptide histatin-1 promotes endothelial cell adhesion, migration, and angiogenesis
(Federation of American Societies for Experimental Biology, 2017)
Saliva is a key factor that contributes to the high efficiency of wound healing in the oral mucosa. This is not only attributed to physical cues but also to the presence of specific peptides in the saliva, such as histatins. ...
TRPC3-GEF-H1 axis mediates pressure overload-induced cardiac fibrosis
(Nature Publishing Group, 2016-12)
Structural cardiac remodeling, accompanying cytoskeletal reorganization of cardiac cells, is a major clinical outcome of diastolic heart failure. A highly local Ca2+ influx across the plasma membrane has been suggested to ...
RabGTPase-mediated trafficking: Its role in neurite formation
(Wiley Blackwell Publishing, Inc, 2014-03)
Neuronal cells are characterized by the presence of two confined domains, which are different in their cellular properties, biochemical functions and molecular identity. The generation of asymmetric domains in neurons ...
Rab-mediated trafficking role in neurite formation
(Wiley Blackwell Publishing, Inc, 2014-04)
Neuronal cells are characterized by the presence of two confined domains, which are different in their cellular properties, biochemical functions and molecular identity. The generation of asymmetric domains in neurons ...
RasGEF1b: localização celular de seus domínios e papel regulador negativo sobre a ativação de NF-kappaB
(Universidade Federal de Minas GeraisUFMG, 2011-07-29)
The guanine nucleotide exchange factor RasGEF1b is a protein encoded by a gene whose expression is strongly induced in response to stimuli with Toll-like receptor (TLR) agonists. RasGEF1b is found localized at the early ...
TRPC3-GEF-H1 axis mediates pressure overload-induced cardiac fibrosis
(Nature Research, 2016)
Abstract: Structural cardiac remodeling, accompanying cytoskeletal reorganization of cardiac cells, is a major clinical outcome of diastolic heart failure. A highly local Ca2+ influx across the plasma membrane has been ...
The RabGEF ALS2 is a hypoxia inducible target associated with the acquisition of aggressive traits in tumor cells
(Nature, 2020)
Tumor hypoxia and the hypoxia inducible factor-1, HIF-1, play critical roles in cancer progression and metastasis. We previously showed that hypoxia activates the endosomal GTPase Rab5, leading to tumor cell migration and ...
The RabGEF ALS2 is a hypoxia inducible target associated with the acquisition of aggressive traits in tumor cells
(2020-12)
Tumor hypoxia and the hypoxia inducible factor-1, HIF-1, play critical roles in cancer progression and metastasis. We previously showed that hypoxia activates the endosomal GTPase Rab5, leading to tumor cell migration and ...