Buscar
Mostrando ítems 41-50 de 79
GMP redutase de Escherichia coli: mecanismos cinéticos, catalíticos e químicos e a termodinâmica da formação do complexo binário de ligação enzima-ligante
(Pontifícia Universidade Católica do Rio Grande do SulPorto Alegre, 2011)
Guanosine monophosphate (GMP) reductase catalyzes the reductive deamination of GMP to inosine monophosphate (IMP). GMP reductase plays an important role in the conversion of nucleoside and nucleotide derivatives of guanine ...
GMP redutase de Escherichia coli: mecanismos cinéticos, catalíticos e químicos e a termodinâmica da formação do complexo binário de ligação enzima-ligante
(Pontifícia Universidade Católica do Rio Grande do SulPorto Alegre, 2011)
Guanosine monophosphate (GMP) reductase catalyzes the reductive deamination of GMP to inosine monophosphate (IMP). GMP reductase plays an important role in the conversion of nucleoside and nucleotide derivatives of guanine ...
Estudos bioquímicos e nocaute gênico da enzima uracil fosforribosil transferase de Mycobacterium tuberculosis como alvo para o desenvolvimento de cepas atenuadas
(Pontifícia Universidade Católica do Rio Grande do SulPorto Alegre, 2011)
Tuberculosis (TB) is an infectious disease mainly caused by Mycobacterium tuberculosis, which currently infects one-third of the world’s population. Despite the availability of the Bacille Calmette-Guérin vaccine and ...
Estudos bioquímicos e nocaute gênico da enzima uracil fosforribosil transferase de Mycobacterium tuberculosis como alvo para o desenvolvimento de cepas atenuadas
(Pontifícia Universidade Católica do Rio Grande do SulPorto Alegre, 2011)
Tuberculosis (TB) is an infectious disease mainly caused by Mycobacterium tuberculosis, which currently infects one-third of the world’s population. Despite the availability of the Bacille Calmette-Guérin vaccine and ...
Caracterização funcional da região promotora do gene Rasgef1b e avaliação de componentes da via de sinalização de receptores do tipo toll (TLRs) sobre sua regulação
(Universidade Federal de Minas GeraisBrasilICB - INSTITUTO DE CIÊNCIAS BIOLOGICASPrograma de Pós-Graduação em Biologia CelularUFMG, 2016-02-19)
The guanine nucleotide exchange factor RasGEF1b is encoded by a gene whose
expression is induced in innate immune cells in response to the activation of Toll-like
receptors (TLRs). RasGEF1b mRNA levels are increased in ...
PTH stimulates PLCβ and PLCγ isoenzymes in rat enterocytes: influence of ageing
(Elsevier Science Inc, 2001-02)
We previously reported that in rat duodenal cells (enterocytes), parathyroid hormone (PTH [1–34]: PTH) stimulates the hydrolysis of polyphosphoinositides by phospholipase C (PLC), generating the second messengers inositol ...
Functional analysis of oxidative burst in sugarcane smut-resistant and -susceptible genotypes
(2017-04-01)
Main Conclusion: Smut pathogen induced an early modulation of the production and scavenging of reactive oxygen species during defence responses in resistant sugarcane that coincided with the developmental stages of fungal ...
The RabGEF ALS2 is a hypoxia inducible target associated with the acquisition of aggressive traits in tumor cells
(Nature, 2020)
Tumor hypoxia and the hypoxia inducible factor-1, HIF-1, play critical roles in cancer progression and metastasis. We previously showed that hypoxia activates the endosomal GTPase Rab5, leading to tumor cell migration and ...
Auto-regulation of Secretory Flux by Sensing and Responding to the Folded Cargo Protein Load in the Endoplasmic Reticulum
(2019-03-07)
Maintaining the optimal performance of cell processes and organelles is the task of auto-regulatory systems. Here we describe an auto-regulatory device that helps to maintain homeostasis of the endoplasmic reticulum (ER) ...
The RabGEF ALS2 is a hypoxia inducible target associated with the acquisition of aggressive traits in tumor cells
(2020-12)
Tumor hypoxia and the hypoxia inducible factor-1, HIF-1, play critical roles in cancer progression and metastasis. We previously showed that hypoxia activates the endosomal GTPase Rab5, leading to tumor cell migration and ...