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¿El ocaso del modelo disociado de acción glucocorticoidea?The twilight of the dissociated model of glucocorticoid action
(Academia Nacional de Ciencias Exactas, Físicas y Naturales, 2020-05)
Los glucocorticoides son hormonas esteroides que participan en la regulación de numerosos procesos fisiológicos y son esenciales para la vida. Desde un punto de vista farmacológico, estas hormonas son utilizadas en la ...
Expression kinetics of glucocorticoid receptor isoforms predicts treatment response to glucocorticoids in uveitis patients
(Association for Research in Vision and Ophthalmology, 2015)
Purpose: Glucocorticoids (GC) have been the mainstay therapy for autoimmue uveitis for decades, but up to one third of patients are unable to achieve disease control at tolerable GC doses, developing vision-threatening ...
Estudio biofísico del mecanismo de acción del receptor de glucocorticoidesBiophysical study of the glucocorticoid receptor mechanism of action
(2018-03-27)
El núcleo celular es una organela con una organización espacial muy compleja. Los componentes responsables de las distintas funciones nucleares, como la replicación y la reparación del ADN, la transcripción y el procesamiento ...
Regulación de las variaciones estacionales en la sensibilidad testicular a la acción de los glucocorticoides en Rhinella arenarum (Amphibia, Anura). Interrelación testículo-interrenalRegulation of seasonal variations in testicular sensitivity to glucocorticoids action in Rhinella arenarum (Amphibia, Anura). Interrelation between testis and interrenal
(Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires, 2012)
Insights into the Therapeutic Potential of Glucocorticoid Receptor Modulators for Neurodegenerative Diseases
(Molecular Diversity Preservation International, 2020-03)
Glucocorticoids are crucial for stress-coping, resilience, and adaptation. However, if the stress hormones become dysregulated, the vulnerability to stress-related diseases is enhanced. In this brief review, we discuss the ...
Corticosterone influences gerbil (Meriones unguiculatus) prostatic morphophysiology and alters its proliferation and apoptosis rates
(2017-06-01)
Glucocorticoids (GCs) are hormones that are widely used in medicine; but although side effects are generally recognised, little is known about the precise mechanisms that is implicated in many of these side effects. ...
Evaluating budesonide efficacy in nasal polyposis and predicting the resistance to treatment
(WILEY-BLACKWELL PUBLISHING, INC, 2009)
Cell resistance to glucocorticoids is a major problem in the treatment of nasal polyposis (NP). The objectives of this study were to observe the effect of budesonide on the expression of IL-1 beta, TNF-alpha, granulocyte ...
Role of glucocorticoid and mineralocorticoid receptors in rainbow trout (Oncorhynchus mykiss) skeletal muscle: A transcriptomic perspective of cortisol action
(Frontiers Media S.A., 2023-01)
Cortisol is an essential regulator of neuroendocrine stress responses in teleost. Cortisol performs its effects through the modulation of glucocorticoid receptor (GR) and mineralocorticoid receptor (MR), activating gene ...