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Gaining Insights Into the Pharmacology of Anthelmintics Using Haemonchus contortus as a Model Nematode
(Elsevier Academic Press Inc, 2016-12)
Progress made in understanding pharmacokinetic behaviour and pharmacodynamic mechanisms of drug action/resistance has allowed deep insights into the pharmacology of the main chemical classes, including some of the few ...
Preventable adverse drug events in critically ill HIV patients: is the detection of potential drug-drug interactions a useful tool?
(Faculdade de Medicina / USP, 2019)
Multidrug resistant tuberculosis
(BMJ Publishing Group, 2015)
Tuberculosis remains a major cause of morbidity and mortality globally, with an estimated nine million people developing the disease and 1.5 million deaths in 2013; equating to 4100 deaths a day.1 Nevertheless, considerable ...
Clinical management of drug-resistant tuberculosis in resource constrained settings
(Sage Publications, 2013-06)
Drug-resistant forms of tuberculosis (TB), particularly multi- and extensively drug-resistant TB, represent an important obstacle to global control of the disease. Recently, new drugs, repurposed drugs, and new drug ...
Incidence of virological failure and major regimen change of initial combination antiretroviral therapy in the Latin America and the Caribbean: An observational cohort study
(Elsevier, 2015)
Background: Access to combination antiretroviral therapy (ART) is expanding in Latin America (Mexico, Central America, and South America) and the Caribbean. We assessed the incidence of and factors associated with regimen ...
Resistencia antimicrobiana en Helicobacter pylori: aspectos clínicos y moleculares
(Sociedad Médica de Santiago, 2003)
Factors associated with early mycological clearance in HIV-associated cryptococcal meningitis
(Public Library of Science, 2017)
Introduction: The first-line combination therapy for HIV-associated cryptococcal meningitis (CM), a condition of high mortality particularly in the first two weeks of treatment, consists of amphotericin B plus flucytosine ...
Morphological changes and differentially expressed efflux pump genes in Mycobacterium tuberculosis exposed to a rifampicin and verapamil combination
(Churchill Livingstone, 2016-03-01)
The aim of the present study was to (i) evaluate the in vitro action of rifampicin (RIF), ethambutol or isoniazid with efflux pumps inhibitors (EPIs) in Mycobacterium tuberculosis (Mtb) H(37)Rv and (ii) evaluate the ...
Leprosy: current situation, clinical and laboratory aspects, treatment history and perspective of the uniform multidrug therapy for all patients
(Sociedade Brasileira de Dermatologia, 2020)
Antifungal drugs combinations: A patent review 2000-2015
(Informa Healthcare, 2016-04)
Introduction: Combination therapy has emerged as an approach to improve the efficacy of antifungal drugs. Its main objective is to achieve synergistic interaction with higher antifungal properties and lower toxic effects ...