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Trypanocidal activity of Piper arboreum and Piper tuberculatum (Piperaceae)
(Sociedade Brasileira de Farmacognosia, 2009)
In the scope of our ongoing research on bioactive agents from Brazilian flora, twenty-four extracts and fractions obtained from Piper arboreum Aub. and Piper tuberculatum Jacq. (Piperaceae) were screened for trypanocidal ...
Atividade tripanocida de Piper arboreum e Piper tuberculatum (Piperaceae)
(Sociedade Brasileira de Farmacognosia, 2009-03-01)
No escopo de nossas pesquisas sobre agentes bioativos da flora brasileira, vinte e quatro extratos e frações de Piper arboreum Aub. e Piper tuberculatum Jacq. (Piperaceae) tiveram sua atividade tripanocida avaliada através ...
Atividade tripanocida de Piper arboreum e Piper tuberculatum (Piperaceae)
(Sociedade Brasileira de Farmacognosia, 2009-03-01)
No escopo de nossas pesquisas sobre agentes bioativos da flora brasileira, vinte e quatro extratos e frações de Piper arboreum Aub. e Piper tuberculatum Jacq. (Piperaceae) tiveram sua atividade tripanocida avaliada através ...
Antiprotozoal Sesquiterpene Pyridine Alkaloids from Maytenus ilicifolia
(Amer Chemical Soc, 2014)
Synthesis, cytotoxicity and in vitro antileishmanial activity of naphthothiazoles
(2013-06-01)
The leishmaniasis is a spectral disease caused by the protozoan Leishmania spp., which threatens millions of people worldwide. Current treatments exhibit high toxicity, and there is no vaccine available. The need for new ...
Leishmania amazonensis META2 protein confers protection against heat shock and oxidative stress
(Elsevier, 2011)
The META cluster of Leishmania amazonensis contains both META1 and META2 genes, which are upregulated in metacyclic promastigotes and encode proteins containing the META domain. Previous studies defined META2 as a 48.0-kDa ...
Patients’ preferences of cutaneous leishmaniasis treatment outcomes: Findings from an international qualitative study
(Public Library of Science, 2020)
BACKGROUND: Cutaneous leishmaniasis (CL) is a disease that often affects exposed skin areas and may heal leaving lifelong scars. Patients' expectations from treatment are rarely considered in drug development for CL. An ...
Synthesis, antileishmanial activity and cytotoxicity of 2,3-diaryl- and 2,3,8-trisubstituted imidazo[1,2-a]pyrazines
(Elsevier, 2015)
A series of original 2-phenyl-3-(pyridin-4-yl)imidazo[1,2-a]pyrazines and the 3-iodo precursors, bearing a polar moiety at the C-8 position, was synthesized and evaluated for their antileishmanial activities. Two derivatives ...
Association of the Endobiont Double-Stranded RNA Virus LRV1 With Treatment Failure for Human Leishmaniasis Caused by Leishmania braziliensis in Peru and Bolivia
(Oxford University Press, 2015)
Cutaneous and mucosal leishmaniasis, caused in South America by Leishmania braziliensis, is difficult to cure by chemotherapy (primarily pentavalent antimonials [Sb(V)]). Treatment failure does not correlate well with ...