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Design, synthesis and biological evaluation of new carboxylic acid derivatives as trans-sialidase inhibitors of trypanosoma cruzi
(2019-12-12)
RESUMEN: La enfermedad de Chagas es una enfermedad crónica mortal que actualmente afecta de 8 a 10 millones de personas en todo el mundo, principalmente en centro y Sudamérica. La Transialidasa de Trypanosoma cruzi (TcTS) ...
High-resolution neutron and X-ray diffraction room-temperature studies of an H-FABP-oleic acid complex: Study of the internal water cluster and ligand binding by a transferred multipolar electron-density distribution
(International Union of Crystallography, 2016-03)
Crystal diffraction data of heart fatty acid binding protein (H-FABP) in complex with oleic acid were measured at room temperature with high-resolution X-ray and neutron protein crystallography (0.98 and 1.90 Å resolution, ...
Amino acid sequence and crystal structure of BaP1, a metalloproteinase from Bothrops asper snake venom that exerts multiple tissue-damaging activities
(Cold Spring Harbor Lab Press, Publications Dept, 2014)
Liver fatty acid-binding protein binds monoacylglycerol in vitro and in mouse liver cytosol.
(American Society for Biochemistry and Molecular Biology, 2013-05-08)
Liver fatty acid-binding protein (LFABP; FABP1) is expressed both in liver and intestinal mucosa. Mice null for LFABP were recently shown to have altered metabolism of not only fatty acids but also monoacylglycerol, the ...
The Caenorhabditis elegans DAF-12 nuclear receptor: Structure, dynamics, and interaction with ligands
(Wiley-liss, Div John Wiley & Sons Inc, 2012-07)
A structure for the ligand binding domain (LBD) of the DAF-12 receptor from Caenorhabditis elegans was obtained from the X-ray crystal structure of the receptor LBD from Strongyloides stercoralis bound to (25R)-Δ7-dafachronic ...
Omega-3 PUFA and aspirin as adjuncts to periodontal debridement in patients with periodontitis and type 2 diabetes mellitus: Randomized clinical trial
(2020-01-01)
Background: Supplementation with omega-3 polyunsaturated fatty acids (ω-3 PUFA) and low-dose aspirin (ASA) have been proposed as a host modulation regimen to control chronic inflammatory diseases. The aim of this study was ...
Mutational analysis of Deinococcus radiodurans bacteriophytochrome reveals key amino acids necessary for the photochromicity and proton exchange cycle of phytochromes
(American Society for Biochemistry and Molecular Biology, 2008-05)
The ability of phytochromes (Phy) to act as photointerconvertible light switches in plants and microorganisms depends on key interactions between the bilin chromophore and the apoprotein that promote bilin attachment and ...
Structural insights into bacterial resistance to cerulenin
(Wiley, 2014-05)
Cerulenin is a fungal toxin that inhibits both eukaryotic and prokaryotic ketoacyl-acyl carrier protein synthases or condensing enzymes. It has been used experimentally to treat cancer and obesity, and is a potent inhibitor ...
Single amino acid mutations in the potato immune receptor R3a expand response to Phytophthora effectors
(American Phytopathological Society, 2014-03)
Both plants and animals rely on nucleotide-binding domain and leucine-rich repeat-containing proteins (NB-LRRs or NLRs) to respond to invading pathogens and activate immune responses. How plant NB-LRR proteins respond to ...
In vitro and in silico studies reveal capsid-mutant Porcine circovirus 2b with novel cytopathogenic and structural characteristics
(2018-06-02)
Porcine circovirus 2 (PCV2) is an icosahedral, non-enveloped, and single-stranded circular DNA virus that belongs to the family Circoviridae, genus Circovirus, and is responsible for a complex of different diseases defined ...