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Participación de los sistemas de muerte post-segregacional en la estabilidad de la resistencia a carbapenémicos en Enterobacterias
(Instituto de BiotecnologíaUniversidad Nacional de Colombia - Sede Bogotá, 2020-01-24)
La circulación de NDM entre enterobacterias representa un serio problema para los sistemas de salud debido a las limitadas opciones terapéuticas disponibles. En la actualidad se sabe que el gen que codifica NDM se originó ...
Desenvolvimento de vacina de liberação controlada contra C. botulinum tipo c e tipo d utilizando quitosana
(Universidade Federal de Minas GeraisUFMG, 2010-10-15)
Single shot vaccines against animal botulism were formulated, using chitosan microspheres prepared through simple coacervation as a controlled release matrix (adjuvant). Partially purified types C and D botulinic toxoids ...
Síntese, estrutura e atividade de peptídeos derivados de ParD, o antídoto do módulo toxina-antitoxina ParDE
(Universidade Estadual Paulista (Unesp), 2014-12-15)
The ParE-ParD system represents a toxin-antitoxin module of the broad host range plasmid RK2. ParE (103 amino acids) is the toxin, whereas ParD (83 amino acids) constitutes the antidote able to neutralize ParE by forming ...
Peptides based on CcdB protein as novel inhibitors of bacterial topoisomerases
(Pergamon-Elsevier B.V. Ltd, 2008-12-01)
The ccd toxin-antitoxin system of the F plasmid encodes CcdB, a protein that poisons the essential Escherichia coli DNA gyrase, unique type IIA topoisomerase able to introduce negative supercoils into DNA. Based on CcdB ...
Peptides based on CcdB protein as novel inhibitors of bacterial topoisomerases
(Pergamon-Elsevier B.V. Ltd, 2008-12-01)
The ccd toxin-antitoxin system of the F plasmid encodes CcdB, a protein that poisons the essential Escherichia coli DNA gyrase, unique type IIA topoisomerase able to introduce negative supercoils into DNA. Based on CcdB ...
Análisis funcional de los genes que codifican al sistema toxina-antitoxina del plásmido pUM505
(Universidad Michoacana de San Nicolás de Hidalgo, 2015-11)
The toxin-antitoxin (TA) systems are small genetic elements consisting of two genes encoding a toxin and an antitoxin. TA systems are distributed among bacteria and have been found in plasmids and chromosomes. They have ...
Anti-Metalloproteases
(2023)
Acinetobacter defence mechanims against biological aggressors and their use as alternative therapeutic applications
(Informa Healthcare, 2021-08)
Several Acinetobacter strains are important nosocomial pathogens, with Acinetobacter baumannii being the species of greatest worldwide concern due to its multi-drug resistance and the recent appearance of hyper-virulent ...