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Pregnancy-specific glycoprotein 1a activates dendritic cells to provide signals for Th17-, Th2-, and Treg-cell polarization
(Wiley VCH Verlag, 2012-06)
Because of their plasticity and central role in orchestrating immunity and tolerance, DCs can respond to pregnancy-specific signals, thus promoting the appropriate immune response in order to support pregnancy. Here, we ...
Zinc Supplementation Attenuates Cardiac Remodeling after Experimental Myocardial Infarction
(2018-10-01)
Background/Aims: The objective of our study was to evaluate the effects of zinc supplementation on cardiac remodeling following acute myocardial infarction in rats. Methods: Animals were subdivided into 4 groups and observed ...
The role of interleukin-6 signalling and its therapeutic blockage in skewing the T cell balance in rheumatoid arthritis
(Wiley, 2017)
Therapeutic blockage of cytokine signalling in autoimmune diseases has improved our understanding of the role of these cytokines in triggering, shaping and perpetuating autoimmune responses. In rheumatoid arthritis (RA), ...
Tr1 cells reside within the tumor microenvironment: Comparison with conventional Foxp3+ T regulatory cells.
(Universidad de Chile, 2019)
Evaluación de la capacidad de linfocitos T reguladores alogénicos para producir tolerancia in vivo
(Universidad de Chile, 2014)
El principal desafío en la investigación de trasplantes es controlar la respuesta inmune generada contra los antígenos del donante, la cual causa el rechazo de los injertos. Promover mecanismos de tolerancia inmunológica ...
Quantificação imunofenotípica de células T reguladoras em cães acometidos por linfoma multicêntrico submetidos ao protocolo quimioterápico chop associado ou não a um firocoxib
(Universidade Estadual Paulista (Unesp), 2014-12-05)
In Veterinary Medicine lymphoma is a neoplasm characterized by clonal proliferation of malignant lymphocytes, one of the most common in dogs. There is evidence that Treg inhibit the effector function against tumors, resulting ...
Polymyxin B increases the depletion of T regulatory cell induced by purinergic agonist
(Elsevier, 2012)
Regulatory T cells (Treg) are important in the development of immune tolerance under normal physiological
conditions. However, in pathological situations such as cancer, Treg increases have been correlated
with bad ...
Orally-induced intestinal CD4+ CD25+ FoxP3+ treg controlled undesired responses towards oral antigens and effectively dampened food allergic reactions
(Public Library of Science, 2015-10)
The induction of peripheral tolerance may constitute a disease-modifying treatment for allergic patients. We studied how oral immunotherapy (OIT) with milk proteins controlled allergy in sensitized mice (cholera toxin plus ...
Interleukin-35 inhibits alveolar bone resorption by modulating the Th17/Treg imbalance during periodontitis
(Wiley, 2020)
Aim T lymphocytes play a central role during the pathogenesis of periodontitis, and the imbalance between the pathogenic T-helper type 17 (Th17) and protective T-regulatory (Treg) lymphocytes determines the tooth-supporting ...