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Mostrando ítems 41-50 de 182
Planejamento in silico e síntese de peptídeos derivados da proteína YjhX: estudos de inibição da atividade de DNA topoisomerases
(Universidade Estadual Paulista (Unesp), 2020-02-19)
O recém-descoberto sistema YjhX-YjhQ bacteriano é um sistema toxina-antitoxina (TA) do tipo II (formado por duas proteínas) que apresenta um grande potencial a ser estudado com o intuito de desenvolver potenciais fármacos, ...
Avaliação de novas estratégias terapêuticas para tratamento de células leucêmicas resistentes a inibidores de topoisomerases
(Universidade Federal de PernambucoUFPEBrasilPrograma de Pos Graduacao em Inovacao Terapeutica, 2018)
Alterations of spermatogenesis in etoposide-treated rats: A stereological study
(Interciencia, 2014)
Two short peptides including segments of subunit A of Escherichia coli DNA gyrase as potential probes to evaluate the antibacterial activity of quinolones
(2001-03-10)
Quinolones constitute a family of compounds with a potent antibiotic activity. The enzyme DNA gyrase, responsible for the replication and transcription processes in DNA of bacteria, is involved in the mechanism of action ...
Two short peptides including segments of subunit A of Escherichia coli DNA gyrase as potential probes to evaluate the antibacterial activity of quinolones
(2001-03-10)
Quinolones constitute a family of compounds with a potent antibiotic activity. The enzyme DNA gyrase, responsible for the replication and transcription processes in DNA of bacteria, is involved in the mechanism of action ...
Extractos vegetales con actividad sobre cepas mutadas de saccharomyces cerevisiae con deficiencia en el mecanismo de reparación del ADN
(Pereira : Universidad Tecnológica de PereiraFacultad de Ciencias Básicas, 2011)
Computational studies, design and synthesis of Pd(II)-based complexes: Allosteric inhibitors of the Human Topoisomerase-IIα
(2019-10-01)
Herein, a robust docking protocol was developed by using a low-cost workflow to highlight the modulation at ATPase domain from Human Topoisomerase-IIα (TOP2A) towards four novel Pd(II)-complexes bearing N,S-donor ligands. ...
Inhibition of human DNA topoisomerase IB by nonmutagenic ruthenium(II)-based compounds with antitumoral activity
(2016-02-01)
Herein we synthesized two new ruthenium(ii) compounds [Ru(pySH)(bipy)(dppb)]PF6 (1) and [Ru(HSpym)(bipy)(dppb)]PF6 (2) that are analogs to an antitumor agent recently described, [Ru(SpymMe2)(bipy)(dppb)]PF6 (3), where ...