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Telomere and Telomerase Biology
(Elsevier B.V., 2015)
The Putative Leishmania Telomerase Rna (leishter) Undergoes Trans-splicing And Contains A Conserved Template Sequence
(Public Library of Science, 2014)
Constitutional hypomorphic telomerase mutations in patients with acute myeloid leukemia
(NATL ACAD SCIENCES, 2009)
Loss-of-function mutations in telomerase complex genes can cause bone marrow failure, dyskeratosis congenita, and acquired aplastic anemia, both diseases that predispose to acute myeloid leukemia. Loss of telomerase function ...
Avaliação da atividade de telomerase em células-tronco embrionáriasindiferenciadas e em células neoplásicas de camundongo
(Universidade Federal de Minas GeraisUFMG, 2008-12-19)
Telomerase is an enzyme which plays a role in the maintenance of theproliferation ability of the cells and in the protection and stabilization of thechromosomes. The main function of telomerase is to add telomere sequences ...
Estudos in vitro da inibição da atividade da telomerase de Leishmania major
(Universidade Estadual Paulista (Unesp), 2018-10-26)
As leishmanioses são doenças tropicais negligenciadas, causadas por protozoários do gênero Leishmania. Elas são consideradas pela Organização Mundial da Saúde como uma doença endêmica em muitos países, incluindo o Brasil. ...
DNA related enzymes as molecular targets for antiviral and antitumoral chemotherapy. A natural overview of the current perspectives
(Bentham Science Publishers, 2019-01)
Background: The discovery of new chemotherapeutic agents still remains a continuous goal to achieve. DNA polymerases and topoisomerases act in nucleic acids metabolism modulating different processes like replication, ...
Chronic in vitro exposure to 3′-azido-2′, 3′-dideoxythymidine induces senescence and apoptosis and reduces tumorigenicity of metastatic mouse mammary tumor cells
(Springer, 2001-03)
Normal cells in culture divide a certain amount of times and undergo a process termed replicative senescence. Telomere loss is thought to control entry into senescence. Activation of telomerase in tumors bypasses cellular ...
Biological actions of the hsp90-binding immunophilins FKBP51 and FKBP52
(Multidisciplinary Digital Publishing Institute, 2019-08)
Immunophilins are a family of proteins whose signature domain is the peptidylprolylisomerase domain. High molecular weight immunophilins are characterized by the additional presence of tetratricopeptide-repeats (TPR) through ...