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Three-dimensional structure of ribonuclease T-1 complexed with an isosteric phosphonate substrate analogue of GpU: Alternate substrate binding modes and catalysis
(Amer Chemical Soc, 1999-02-23)
The X-ray crystal structure of a complex between ribonuclease T-1 and guanylyl(3'-6')-6'-deoxyhomouridine (GpcU) has been determined at 2.0 Angstrom resolution. This Ligand is an isosteric analogue of the minimal RNA ...
Odorant recognition using biological responses recorded in olfactory bulb of rats
(Elsevier, 2015)
In this study we applied pattern recognition (PR) techniques to extract odorant information from local
field potential (LFP) signals recorded in the olfactory bulb (OB) of rats subjected to different odorant
stimuli. We ...
Structural insights into substrate binding of brown spider venom class ii phospholipases d
(2015-09-01)
Phospholipases D (PLDs), the major dermonecrotic factors from brown spider venoms, trigger a range of biological reactions both in vitro and in vivo. Despite their clinical relevance in loxoscelism, structural data is ...
A Gatekeeper Residue of ClpS1 from Arabidopsis thaliana Chloroplasts Determines its Affinity Towards Substrates of the Bacterial N-End Rule
(Oxford University Press, 2018-03)
Proteins that are to be eliminated must be proficiently recognized by proteolytic systems so that inadvertent elimination of useful proteins is avoided. One mechanism to ensure proper recognition is the presence of N-terminal ...
Serotonergic modulation of face-emotion recognition
(Associação Brasileira de Divulgação Científica, 2008)
Facial expressions of basic emotions have been widely used to investigate the neural substrates of emotion processing, but little is known about the exact meaning of subjective changes provoked by perceiving facial ...
Chemical recognition in a snake-lizard predator-prey system
(Springer, 2015)
In a predator-prey interaction, the fitnesses of the predator and the prey depend on their abilities to recognize each other, a process that may involve different sensory modalities. Squamate reptiles are highly dependent ...
Insulin-degrading enzyme: Structure-function relationship and its possible roles in health and disease
(Bentham Science Publishers, 2009-11)
Insulin-degrading enzyme (IDE) or insulysin is a highly conserved Zn 2+-dependent endopeptidase with an "inverted" HxxEH motif. In vivo, IDE contributes to regulate the steady state levels of peripheral insulin and cerebral ...
Exploring the role of residue 228 in substrate and inhibitor recognition by VIM Metallo-β-lactamases
(American Chemical Society, 2015-05)
β-Lactamase inhibitors (BLIs) restore the efficacy of otherwise obsolete β-lactams. However, commercially available BLIs are not effective against metallo-β-lactamases (MBLs), which continue to be disseminated globally. ...