Buscar
Mostrando ítems 41-50 de 213
DNA strand breaks and base modifications induced by cholesterol hydroperoxides
(INFORMA HEALTHCARE, 2011)
Cholesterol (Ch) can be oxidized by reactive oxygen species, forming oxidized products such as Ch hydroperoxides (ChOOH). These hydroperoxides can disseminate the peroxidative stress to other cell compartments. In this ...
Jumonji Inhibitors Overcome Radioresistance in Cancer through Changes in H3K4 Methylation at Double-Strand Breaks
(Elsevier, 2018-10)
We have uncovered a role for Jumonji inhibitors in overcoming radioresistance through KDM5B inhibition. Pharmacological blockade of Jumonji demethylases with JIB-04 leads to specific accumulation of H3K4me3 at sites marked ...
Variants in DNA double-strand break repair genes and risk of familial breast cancer in a South American population
(2010)
The double-strand break (DSB) DNA repair
pathway has been implicated in breast cancer (BC).
RAD51 and its paralogs XRCC3 and RAD51D play an
important role in the repair of DSB through homologous
recombination (HR). ...
Response of the G2-prophase checkpoint to genotoxic drugs in lymphocytes from healthy individuals
(Society of Biology of Chile, 2012)
We analyzed the in vitro effects of the anti-tumoral drugs doxorubicin, cytosine arabinoside and hydroxyurea on the G2-prophase checkpoint in lymphocytes from healthy individuals. At biologically equivalent concentrations, ...
Estudo sobre o reparo por recombinação homóloga em diferentes linhagens de Trypanosoma cruzi
(Universidade Federal de Minas GeraisUFMG, 2015-08-07)
Trypanosoma cruzi is the etiological agent of Chagas Disease. The variety of symptoms of Chagas disease can be associated with the genetic variability of different strains of Trypanosoma cruzi. Studies of infection with ...
Chk1 phosphorylation of Metnase enhances DNA repair but inhibits replication fork restart
(NATURE PUBLISHING GROUPLONDON, 2012)
Chk1 both arrests replication forks and enhances repair of DNA damage by phosphorylating downstream effectors. Although there has been a concerted effort to identify effectors of Chk1 activity, underlying mechanisms of ...
Nonrecurrent MECP2 duplications mediated by genomic architecture-driven DNA breaks and break-induced replication repair
(COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT, 2008)
Recurrent submicroscopic genomic copy number changes are the result of nonallelic homologous recombination (NAHR). Nonrecurrent aberrations, however, can result from different nonexclusive recombination-repair mechanisms. ...
Estudo sobre o reparo por recombinação homóloga em diferentes linhagens de Trypanosoma cruzi
(Universidade Federal de Minas GeraisBrasilICB - DEPARTAMENTO DE BIOLOGIA GERALPrograma de Pós-Graduação em GenéticaUFMG, 2015-08-07)
cruzi and their phylogenetic relationships, phylogeny studies recently subdivided T. cruzi into six discrete taxonomic units, named T. cruzi I to T. cruzi VI. Even though reports the occurrence of recombination events are ...
Differential contribution of HP1 proteins to DNA end resection and homology-directed repair
(Taylor & Francis, 2013-02)
Heterochromatin protein 1 paralogs (HP1α, β and γ in mammals) are not only central in heterochromatin organization, but have also been linked to transcriptional activation at euchromatic regions, maintenance of telomere ...