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Stability of single copy transgene expression in CHOK1 cells is affected by histone modifications but not by DNA methylation
(Elsevier, 2014-12)
tIntraclonal heterogeneity of genetically modified mammalian cells has been observed as a phenomenonthat has a strong impact on overall transgene expression levels and that limits the predictability of trans-gene expression ...
Stable and high expression of Galectin-8 tightly controls metastatic progression of prostate cancer
(Impact Journals LLC, 2017-03)
Two decades ago, Galectin-8 was described as a prostate carcinoma biomarker since it is only expressed in the neoplastic prostate, but not in the healthy tissue. To date, no biological function has been attributed to ...
Expression Analysis of Wound Healing Genes in Human Periapical Granulomas of Progressive and Stable Nature
(ELSEVIER SCIENCE INCNEW YORK, 2012)
Introduction: Wound healing process involves the activation of extracellular matrix components, remodeling enzymes, cellular adhesion molecules, growth factors, cytokines and chemokines genes. However, the molecular patterns ...
Development of lentiviral vectors for transient and stable protein overexpression in mammalian cells: A new strategy for recombinant human FVIII (rhFVIII) production
(Elsevier, 2013-11)
Background: Recombinant protein overexpression in mammalian cells constitutes a real challenge in therapeutic protein production. Following the discovery of intron functionality in gene expression, various expression vectors ...
Characterization of hepatitis B virus surface antigen particles expressed in stably transformed mammalian cell lines containing the large, middle and small surface protein
(Elsevier Science, 2020-11)
Vaccination still represents the most efficient and inexpensive strategy in the control of hepatitis B virus (HBV) infection. However, about 10% of the population vaccinated with the current yeast derived vaccine, consisting ...
Stable satellites around extrasolar giant planets
(Wiley-Blackwell, 2006-12-11)
In this work, we study the stability of hypothetical satellites of extrasolar planets. Through numerical simulations of the restricted elliptic three-body problem we found the borders of the stable regions around the ...
Stable satellites around extrasolar giant planets
(Wiley-Blackwell, 2006-12-11)
In this work, we study the stability of hypothetical satellites of extrasolar planets. Through numerical simulations of the restricted elliptic three-body problem we found the borders of the stable regions around the ...
Development of a new promoter to avoid the silencing of genes in the production of recombinant antibodies in chinese hamster ovary cells
(BioMed Central Ltd., 2019)
Background: The production of recombinant proteins in mammalian cell lines is one of the most important areas in biopharmaceutical industry. Viral transcriptional promoters are widely used to express recombinant proteins ...