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Sonic hedgehog (Shh)-Gli signaling controls neural progenitor cell division in the developing tectum in zebrafish
(2011)
Despite considerable progress, the mechanisms that control neural progenitor differentiation and behavior, as well as their functional integration into adult neural circuitry, are far from being understood. Given the ...
Downregulation of the Sonic Hedgehog/Gli pathway transcriptional target Neogenin-1 is associated with basal cell carcinoma aggressiveness
(Impact Journals Llc., 2017)
Basal Cell Carcinoma (BCC) is one of the most diagnosed cancers worldwide. It develops due to an unrestrained Sonic Hedgehog (SHH) signaling activity in basal cells of the skin. Certain subtypes of BCC are more aggressive ...
Sonic Hedgehog modulates EGFR dependent proliferation of neural stem cells during late mouse embryogenesis through EGFR transactivation
(2013-09)
Sonic Hedgehog (Shh/GLI) and EGFR signaling pathways modulate Neural Stem Cell (NSC) proliferation. How these signals cooperate is therefore critical for understanding normal brain development and function. Here we report ...
Cross‐talk between monocyte invasion and astrocyte proliferation regulates scarring in brain injury
(Nature Publishing Group, 2018-05)
Scar formation after brain injury is still poorly understood. To further elucidate such processes, here, we examine the interplay between astrocyte proliferation taking place predominantly at the vascular interface and ...
Avaliação imunoistoquímica da via de sinalização Hedgehog no carcinoma hepatocelular e correlação com fatores prognósticos
(Universidade Federal de Minas GeraisBrasilMED - DEPARTAMENTO DE ANATOMIA PATOLÓGICA E MEDICINA LEGALPrograma de Pós-Graduação em PatologiaUFMG, 2019-08-02)
Introduction: hepatocellular carcinoma (HCC) is the most common primary malignant neoplasm in the liver, with an increase in its incidence and mortality with advancing age. This neoplasm is closely associated with hepatic ...
Differential inflammatory landscape stimulus during titanium surfaces obtained osteogenic phenotype
(2019-08-01)
Molecular mechanism governing inflammatory scenario in response to titanium (Ti)-nanotexturing surfaces needs to be better addressed. Thus, we subjected pre-osteoblast to different Ti-texturing surfaces, as follows: machined ...
Proliferation of Murine Midbrain Neural Stem Cells Depends upon an Endogenous Sonic Hedgehog (Shh) Source
(PLoS ONE, 2013)
The Sonic Hedgehog (Shh) pathway is responsible for critical patterning events early in development and for regulating the
delicate balance between proliferation and differentiation in the developing and adult vertebrate ...