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Small GTpases in acrosomal exocytosis
(Springer, 2015-01)
Regulated exocytosis employs a conserved molecular machinery in all secretory cells. Soluble N -ethylmaleimide-sensitive factor attachment protein receptor (SNARE) and Rab superfamilies are members of this machinery. Rab ...
Timing of novel drug 1a-116 to circadian rhythms improves therapeutic effects against glioblastoma
(Multidisciplinary Digital Publishing Institute, 2021-07)
The Ras homologous family of small guanosine triphosphate-binding enzymes (GTPases) is critical for cell migration and proliferation. The novel drug 1A-116 blocks the interaction site of the Ras-related C3 botulinum toxin ...
Jararhagin, a snake venom metalloprotease-disintegrin, activates the Rac1 GTPase and stimulates neurite outgrowth in neuroblastoma cells
(PERGAMON-ELSEVIER SCIENCE LTD, 2008)
It has been shown previously that the snake venom metalloprotease-disintegrin jararhagin stimulates cell migration and cytoskeletal rearrangement, independently of its effects on cellular adhesion but possibly associated ...
Heterotrimeric Gi Proteins link Hedgehog signaling to activation of Rho small GTPases to promote fibroblast migration
(American Society For Biochemistry And Molecular Biology, 2011-07)
Evidence supporting the functionality of Smoothened (SMO), an essential transducer in most pathways engaged by Hedgehog (Hh), as a Gi-coupled receptor contrasts with the lack of an apparently consistent requirement for Gi ...
Epidermal growth factor receptor controls glycogen phosphorylase in T cells through small GTPases of the RAS family
(American Society for Biochemistry and Molecular Biology, 2019-03-22)
We recently uncovered a regulatory pathway of the muscle isoform of glycogen phosphorylase (PYGM) that plays an important role in regulating immune function in T cells. Here, using various enzymatic, pulldown, and ...
Mcardle disease: New insights into its underlying molecular mechanisms
(Molecular Diversity Preservation International, 2019-12)
McArdle disease, also known as glycogen storage disease type V (GSDV), is characterized by exercise intolerance, the second wind phenomenon, and high serum creatine kinase activity. Here, we recapitulate PYGM mutations in ...
RAP1-RAC1 Signaling Has an Important Role in Adhesion and Migration in HNSCC
(2020-07-01)
Cell-cell adhesion is a key mechanism to control tissue integrity and migration. In head and neck squamous cell carcinoma (HNSCC), cell migration facilitates distant metastases and is correlated with poor prognosis. RAP1, ...
Relevance of small GTPase Rac1 pathway in drug and radio-resistance mechanisms: Opportunities in cancer therapeutics
(Elsevier Science Inc, 2018-04)
Rac1 GTPase signaling pathway has a critical role in the regulation of a plethora of cellular functions governing cancer cell behavior. Recently, it has been shown a critical role of Rac1 in the emergence of resistance ...
PKA-dependent phosphorylation of LIMK1 and Cofilin is essential for mouse sperm acrosomal exocytosis
(Elsevier, 2015-07-10)
Mammalian sperm must acquire their fertilizing ability after a series of biochemical modifications in the female reproductive tract collectively called capacitation to undergo acrosomal exocytosis, a process that is essential ...