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Conformational analyses and docking studies of a series of 5-nitrofuran- and 5-nitrothiophen-semicarbazone derivatives in three possible binding sites of trypanothione and glutathione reductases
(Elsevier B.V., 2006-03-01)
To explore three possible binding sites of trypanothione and glutathione reductase, namely, the active, the dimer interface and the coenzyme NADPH binding site, a series of eight compounds, nitrofurans and nitrothiophenes ...
Novel antitrypanosomal agents based on palladium nitrofurylthiosemicarbazone complexes: DNA and redox metabolism as potential therapeutic targets
(AMER CHEMICAL SOC, 2006-06-01)
In the search for new therapeutic tools against American Trypanosomiasis palladium complexes with bioactive nitrofuran-containing thiosemicarbazones as ligands were obtained. Sixteen novel palladium (II) complexes with the ...
Use of clomipramine as chemotherapy of the chronic phase of Chagas disease
(Cambridge University Press, 2013-02)
Chagas infection is a major endemic disease affecting Latin American countries. The persistence of Trypanosoma cruzi generates a chronic inflammatory reactivity that induces an immune response directed to the host’s tissues. ...
Redox metabolism in Trypanosoma cruzi: Functional characterization of tryparedoxins revisited
(Elsevier Science IncNew YorkEUA, 2013)
Functional characterisation of the methionine sulfoxide reductase repertoire in Trypanosoma brucei
(Elsevier Science Inc, 2017-11)
To combat the deleterious effects that oxidation of the sulfur atom in methionine to sulfoxide may bring, aerobic cells express repair pathways involving methionine sulfoxide reductases (MSRs) to reverse the above reaction. ...
Functional characterization of methionine sulfoxide reductase A from Trypanosoma spp.
(Elsevier Science Inc, 2011-01)
Methionine is an amino acid susceptible to being oxidized to methionine sulfoxide (MetSO). The reduction of MetSO to methionine is catalyzed by methionine sulfoxide reductase (MSR), an enzyme present in almost all organisms. ...
Redox metabolism in Trypanosoma cruzi: functional characterization of tryparedoxins revisited
(Elsevier, 2013-10)
Tryparedoxins (TXNs) are multipurpose oxidoreductases from trypanosomatids that transfer reducing equivalents from trypanothione to different thiol proteins. In Trypanosoma cruzi, two genes coding for TXN like proteins ...