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Nitric oxide potentiation of the homomeric ρ1 GABAC receptor function
(Wiley Blackwell Publishing, Inc, 2012-11)
BACKGROUND AND PURPOSE NO is a highly diffusible and reactive gas produced in the nervous system, which acts as a neuronal signal mediating physiological or pathological mechanisms. NO can modulate the activity of ...
Structure and function development during evolution of pentameric ligand gated ion channels
(Smart Science and Technology, 2016-01)
Ligand Gated Ion Channels (LGICs) are receptors widely involved in vertebrate neuronal and non-neuronal signalling as well as muscle activation. Until very recently these receptors, were only known to exist in animal cells ...
Allosteric modulation of retinal GABA receptors by ascorbic acid
(Society for Neuroscience, 2011-04)
Ionotropic GABA receptors (GABAA and GABAC) belong to the Cys-loop receptor family of ligand-gated ion channels. GABAC receptors are highly expressed in the retina, mainly localized at the axon terminals of bipolar cells. ...
An intracellular redox sensor for reactive oxygen species at the M3-M4 linker of GABAArho1 receptors
(Wiley, 2014-04-11)
Background and Purpose: Reactive oxygen species (ROS) are normally involved in cell oxidative stress but also play a role as cellular messengers in redox signalling; for example, modulating the activity of neurotransmitter ...
A Cys-loop mutation in the Caenorhabditis elegans nicotinic receptor subunit UNC-63 impairs but does not abolish channel function
(American Society for Biochemistry and Molecular Biology, 2011-01-28)
The nematode Caenorhabditis elegans is an established model organism for studying neurobiology. UNC-63 is a C. elegans nicotinic acetylcholine receptor (nAChR) α-subunit. It is an essential component of the levamisole-sensitive ...
Activation and modulation of the caenorhabditis elegans serotonin-gated chloride channel
(Fundación Revista Medicina, 2019)
Serotonin-gated ion channels (5-HT3) belong to the family of Cys-loop receptors, which are pentameric proteins that mediate fast synaptic transmission. In mammals, 5- HT3 are non-selective cationic channels that can be ...
Modulación por óxido nítrico de receptores ionotrópicos de GABANitric oxide modulation of ionotropic GABA Receptors
(Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires, 2014)