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Mostrando ítems 41-50 de 66
Ação antioxidante e neuroprotetora de derivados pirazolínicos inéditos
(Universidade Federal de Santa MariaBRFarmacologiaUFSMPrograma de Pós-Graduação em Farmacologia, 2008-03-28)
Oxidative stress is involved in several neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease and amyotrophic lateral sclerosis. Oxidative stress
seems to be involved in the pathology of dementia/amnesia. ...
In vitro and in vivo trypanocidal activity of H2bdtc-loaded solid lipid nanoparticles
(Public Library of ScienceSan Francisco, 2014-05)
The parasite Trypanosoma cruzi causes Chagas disease, which remains a serious public health concern and continues to victimize thousands of people, primarily in the poorest regions of Latin America. In the search for new ...
Síntese de (5-trifluormetil-1H-pirazol-1-IL)(quinolin-4-IL)metanonas de interesse farmacológico
(Universidade Federal de Santa MariaBRQuímicaUFSMPrograma de Pós-Graduação em Química, 2016-07-22)
A convergent synthesis of a series of 16 new polysubstituted (5-hydroxy-5-(trifluoromethyl)-4,5-dihydro-1H-pyrazol-1-yl)(quinolin-4-yl)methanones, starting from isatin and alky(aryl/heteroaryl) ketones, is described. The ...
Síntese de novos azóis derivados da 1,1- difenilacetona
(Universidade Federal de Santa MariaBRQuímicaUFSMPrograma de Pós-Graduação em Química, 2014-08-07)
This work describes an efficient method to obtaining new heterocycles from the reaction of acetalization of the ketonic carbonyl, followed by acylation of the enolether, generated in situ from the acetal derivative of ...
Síntese regiosseletiva de novas (4,5-diidropirazol-1-il)(-pirimidin-4-il)metanonas com potencial farmacológico
(Universidade Federal de Santa MariaBrasilQuímicaUFSMPrograma de Pós-Graduação em QuímicaCentro de Ciências Naturais e Exatas, 2016-10-20)
This study shows the synthesis of five new 6-substituted 2-methylthio-4-pyrimidine carbohydrazides, aryl groups having such substituents (Ph, 4-FC6H4, 4-BrC6H4, 4-MeC6H4, 4-MeOC6H4) from the nucleophilic substitution of ...
Síntese de 2-[3h-pirazol-2-il]trifluormetilpirimidinas Alquil, aril e heteroaril substituidas
(Universidade Federal de Santa MariaBRQuímicaUFSMPrograma de Pós-Graduação em Química, 2004-07-14)
This work describes a general methodology for the synthesis of a novel series of 4-alkyl, 4-aryl, heteroaryl-2-[5-methyl-4-(2-hidroxyethyl)-3-oxo-1,2-dihydro-3H-pyrazol-2-yl]-6(4)-trifluoromethylpyrimidines. The precursors ...
Plant regeneration of ilex paraguariensis (aquifoliaceaé) by in vitro culture of nodal segments
(Sociedades Latinoamericanas de Microscopia Electrónica. Centro Regional de Investigaciones Científicas y Tecnológicas, 2020-04)
In vitro regeneration of complete plants ffom nodal single bud segments of “yerba mate” {Ilex
paraguariensis St. Hil.) was studied under defined nutritional and environmental conditions. Nodal segments harvested ffom ...
N-alquilação regiosseletiva de pirazóis empregando 4-alcóxi(amino)-5-bromo-1,1,1-trifluorpent-3-en-2-onas
(Universidade Federal de Santa MariaBRQuímicaUFSMPrograma de Pós-Graduação em Química, 2016-08-19)
This work presents the synthesis of three new series of nitrogen-heterocycles containing the substituent trifluoromethyl, exploiting the synthetic versatility and regioselectivity of 4-alkoxy-5-bromo-1,1,1-trifluorpent-3-en-2-ones ...
Condensação de knoevenagel na síntese de novos sistemas heteroaroil-cumarínicos trifluormetil substituídos
(Universidade Federal de Santa MariaBRQuímicaUFSMPrograma de Pós-Graduação em Química, 2014-03-19)
With the aim to verify the influence of the presence of the trifluoromethyl group and the heterocyclic precursor in the heteroaroyl-coumarin synthesis, this dissertation describes firstly a methodology optimization to ...
Síntese e atividades antimicrobiana/antioxidante de 5-trifluormetil-5-hidróxi-4,5-diidro-1h-pirazóis 1-(2-naftoxiacetil), 1-fenoxiacetil, 1-tiofenoxiacetil, 1-(n-fenilglicina) substituídos
(Universidade Federal de Santa MariaBRQuímicaUFSMPrograma de Pós-Graduação em Química, 2011-07-01)
This work describes an efficient approach for the regioselective synthesis of
new series of substituted 1-(2-naphthoxyacetyl), 1-phenoxyacetyl, 1-thiophenoxyacetyl,
1-(N-phenylglicine)-5-trifluoromethyl-5-hydroxy-4,5-dih ...