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Synthesis of conformationally locked carbocyclic nucleosides built on an oxabicyclo[3.1.0]hexane system
(Pergamon-Elsevier Science Ltd, 2003-01)
The rigid 6-oxobicyclo[3.1.0]hexane scaffold, characteristic of the natural antibiotic neplanocin C (3), was used to build prototypes of conformationally locked deoxynucleosides in the North hemisphere of the pseudorotational ...
Cutaneous adverse reaction to 2-chlorodeoxyadenosine with histological flame figures in patients with chronic lymphocytic leukaemia
(Blackwell Publishing LtdOxfordInglaterra, 2004)
Síntese de ácidos anacárdicos e análogos, candidatos a inibidores da enzima gliceraldeido-3-fosfato desidrogenase glicossomal de Trypanosoma cruzi
(Universidade Federal de São CarlosBRUFSCarPrograma de Pós-Graduação em Química - PPGQ, 2007-05-18)
Chagas disease, caused by Trypanosoma cruzi, is endemic in 15 countries in Latin America, including Brazil, and it is estimated that about 16 million people are infected by this protozoan. The enzyme glyceraldehyde-3- ...
Hypoxanthine-Guanine Phosphoribosyltransferase/adenylate Kinase From Zobellia galactanivorans: A Bifunctional Catalyst for the Synthesis of Nucleoside-5′-Mono-, Di- and Triphosphates
(Frontiers in Bioengineering and Biotechnology, 2020)
Biotransformation of halogenated nucleosides by immobilized Lactobacillus animalis 2′- N -deoxyribosyltransferase
(Elsevier Science Sa, 2016-06)
An immobilized biocatalyst with 2′-N-deoxyribosyltransferase (NDT) activity, Lactobacillus animalis NDT (LaNDT), was developed from cell free extracts. LaNDT was purified, characterized and then immobilized by ionic ...
Zoledronate repositioning as a potential trypanocidal drug: Trypanosoma cruzi HPRT an alternative target to be considered
(Pergamon-Elsevier Science Ltd, 2021-06)
Chagas disease is caused by the protozoan parasite Trypanosoma cruzi and affects 7 million people worldwide. Considering the side effects and drug resistance shown by current treatments, the development of new anti-Chagas ...
Radioresistance of adenine to cosmic rays
(2017)
The presence of nucleobases in carbonaceous meteorites on Earth is an indication of the existence of this class of molecules in outer space. However, space is permeated by ionizing radiation, which can have damaging effects ...
Síntese de candidatos a inibidores da enzima 5’-metiltioadenosina/S-adenosilhomocisteína nucleosidase, potenciais agentes antiparasitários
(Universidade Federal de Juiz de Fora (UFJF)BrasilICE – Instituto de Ciências ExatasPrograma de Pós-graduação em QuímicaUFJF, 2019)
Hairy cell leukemia, an uncommon B-cell lymphoid neoplasia
(UANL. Facultad de Medicina, 2016)
Anemia hemolítica auto-imune e outras manifestações imunes da leucemia linfocítica crônica
(Associação Brasileira de Hematologia e Hemoterapia e Terapia Celular, 2005-12-01)
Chronic lymphocytic leukemia (CLL) is frequently associated with autoimmune diseases directed against hematopoietic cells, including autoimmune hemolytic anemia (AIHA), immune thrombocytopenic purpura (ITP), pure red cell ...