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PTEN Directly Activates the Actin Depolymerization Factor Cofilin-1 During PGE(2)-Mediated Inhibition of Phagocytosis of Fungi
(AMER ASSOC ADVANCEMENT SCIENCEWASHINGTON, 2012)
Macrophage ingestion of the yeast Candida albicans requires its recognition by multiple receptors and the activation of diverse signaling programs. Synthesis of the lipid mediator prostaglandin E-2 (PGE(2)) and generation ...
Oxidative stress promotes T dephosphorylation in neuronal cells: The roles of cdk5 and pp1
(PERGAMON-ELSEVIER SCIENCE LTD, 2004-06-01)
Oxidative stress has been demonstrated to produce modifications in several intracellular proteins that lead to alterations in their activities. Alzheimer's disease is related to an increase of oxidative stress markers, ...
Differential Recruitment of Tetratricorpeptide Repeat Domain Immunophilins to the Mineralocorticoid Receptor Influences both Heat-Shock Protein 90-Dependent Retrotransport and Hormone-Dependent Transcriptional Activity
(American Chemical Society, 2007-11)
The mineralocorticoid receptor (MR) forms oligomers with the heat-shock protein 90 (Hsp90) -based heterocomplex, which contains tetratricopeptide repeat (TPR) domain immunophilins (IMMs). Here we investigated the unknown ...
[D-Leu1]MC-LR has lower PP1 inhibitory capability and greater toxic potency than MC-LR in animal and plant tissues
(Multidisciplinary Digital Publishing Institute, 2020-10-01)
Two microcystins, MC-LR and [D-Leu1]MC-LR, present in La Plata Basin blooms, are differentiated by substitution of D-Alanine for D-Leucine at position 1. Our objective was to evaluate acute toxicity of [D-Leu1]MC-LR and ...
Salicylates dilate blood vessels through inhibiting PYK2-mediated RhoA/Rho-kinase activation
(OXFORD UNIV PRESS, 2009)
Aims Compared with other non-steroid anti-inflammatory drugs (NSAIDs), aspirin is not correlated to hypertension. It has been shown that aspirin has unique vasodilator action in vivo, offering an explanation for the unique ...
The Hsp90-binding immunophilin FKBP52 fosters neurodifferentiation and neuroregeneration in murine models
(Shenyang Editorial Dept Neural Regeneration Res, 2021-02)
The term immunophilin involves a family of proteins whose signature domain shows peptidyl-prolyl-(cis/trans)-isomerase (PPIase) enzymatic activity, i.e., the reversible cis/trans interconversion of Xaa-Pro bonds (Erlejman ...
Effects of Lidocaine Infusion during Experimental Endotoxemia in Horses
(Wiley-Blackwell, 2010-07-01)
BackgroundThe clinical efficacy of IV infusion of lidocaine for treatment of equine endotoxemia has not been studied.HypothesisLidocaine infusion after exposure to lipopolysaccharide (LPS) will inhibit the inflammatory ...
Effects of Lidocaine Infusion during Experimental Endotoxemia in Horses
(Wiley-Blackwell, 2010-07-01)
BackgroundThe clinical efficacy of IV infusion of lidocaine for treatment of equine endotoxemia has not been studied.HypothesisLidocaine infusion after exposure to lipopolysaccharide (LPS) will inhibit the inflammatory ...