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Modulation of P75NTR/PRONGEF as a therapeutic approach for degenerative retinopathies
(Royal Society of Chemistry, 2018)
This chapter describes the experimental validation of neurotrophins / neurotrophin receptors as therapeutic targets for the treatment of retinal neurodegenerative disorders. Neuropathies often have inflammatory or vascular ...
Leprosy patients: neurotrophic factors and axonal markers in skin lesions
(Academia Brasileira de Neurologia (ABNEURO), 2012-04-01)
Neurotrofinas são fatores de crescimento com papel fundamental na fisiopatologia neural. Esses mediadores modulam funcionalmente fibras nociceptivas. Mudanças em sua expressão têm sido relacionadas à perda precoce da ...
Leprosy patients: neurotrophic factors and axonal markers in skin lesions
(Academia Brasileira de Neurologia (ABNEURO), 2012-04-01)
Neurotrofinas são fatores de crescimento com papel fundamental na fisiopatologia neural. Esses mediadores modulam funcionalmente fibras nociceptivas. Mudanças em sua expressão têm sido relacionadas à perda precoce da ...
Avaliação de marcadores de diferenciação em células de Schwann murinas submetidas à infecção por Mycobacterium leprae
(Universidade Estadual Paulista (Unesp), 2017-08-03)
A infecção por Mycobacterium leprae (M. leprae) desencadeia alterações no status funcional das células de Schwann (SCs), responsáveis pela produção da bainha de mielina e homeostasia neural. Estudos prévios indicam que ...
Myelination key factor krox-20 is downregulated in Schwann cells and murine sciatic nerves infected by Mycobacterium leprae
(Wiley-Blackwell, 2019-04-01)
Schwann cells (SCs) critically maintain the plasticity of the peripheral nervous system. Peripheral nerve injuries and infections stimulate SCs in order to retrieve homeostasis in neural tissues. Previous studies indicate ...
Hypothyroidism in the Adult Rat Causes Incremental Changes in Brain-Derived Neurotrophic Factor, Neuronal and Astrocyte Apoptosis, Gliosis, and Deterioration of Postsynaptic Density
(MARY ANN LIEBERT, INC, 2012)
Background: Adult hypothyroidism is a highly prevalent condition that impairs processes, such as learning and memory. Even though tetra-iodothyronine (T-4) treatment can overcome the hypothyroidism in the majority of cases, ...
La extensión de ramas colaterales luego de una lesión a la médula espinal es gatillada por la degeneración axonal y depende de la expresión del receptor de neurotrofinas p75
(2013)
Las lesiones a la médula espinal (LME) presentan un pronóstico de recuperaciónprácticamente nulo debido a la baja capacidad regenerativa que tiene el sistema nervioso central (SNC) de los mamíferos. Este hecho estaría ...
An Agonistic mAb Directed to the TrkC Receptor Juxtamembrane Region Defines a Trophic Hot Spot and Interactions with p75 Coreceptors
(2010)
The D5 domain of TrkC receptors is a docking site for Neurotrophin-3 (NT-3), but other domains may be relevant for function or harmonizing signals with p75(NTR) coreceptors. We report a monoclonal antibody (mAb) 2B7 targeting ...
Neurotrophin Signaling Impairment by Viral Infections in the Central Nervous System
(SPRINGER INTERNATIONAL PUBLISHING AG, 2022)
Neurotrophins, such as nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), and neurotrophin 3 (NT-3), NT-4, and NT-5, are proteins involved in several important functions of the central nervous system. The ...
Leprosy patients: neurotrophic factors and axonal markers in skin lesions
(Academia Brasileira de Neurologia (ABNEURO), 2014)