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Cardiac autonomic denervation and expression of neurotrophins (ngf and bdnf) and their receptors during experimental chagas disease
(Universidade Federal de Minas GeraisBrasilICB - DEPARTAMENTO DE MORFOLOGIAUFMG, 2017)
Embora a disautonomia cardíaca seja uma característica distintiva da doença de Chagas, seu significado clínico e funcional ainda é especulado. Fatores neurotróficos estão potencialmente envolvidos; entretanto, estudos sobre ...
Efectos de las hormonas ováricas sobre la expresión de neurotrofinas y proneurotrofinas en el cerebro basal anterior de la rata y su importancia en la sobrevida y muerte neuronal
(2012-08-28)
RESUMEN:
Las neuronas del cerebro basal anterior (CBA) proveen la fuente principal de innervación colinérgica al hipocampo y a la corteza cerebral donde se regulan en gran parte los procesos cognitivos. Las lesiones o ...
Brain-derived neurotrophic factor facilitates TrkB down-regulation and neuronal injury after status epilepticus in the rat hippocampus
(Wiley Blackwell Publishing, Inc, 2009-10-23)
Brain-derived neurotrophic factor (BDNF) is involved in many aspects of neuronal biology and hippocampal physiology. Status epilepticus (SE) is a condition in which prolonged seizures lead to neuronal degeneration. SE-induced ...
Study of the function of p75 neurotrophin receptor on the maturation of adult neuromuscular junctionEstudio de la funcion del receptor de neurotrofinas p75 sobre la maduracion de la union neuromuscular adulta
(2018)
The neuromuscular junction (NMJ) is a peripheral cholinergic synapse formed between a motor axon, a skeletal muscle fiber, and terminal Schwann cells. The maturation of the NMJ includes a morphological, structural and ...
Caracterização ultraestrutural de terminações nervosas autonômicas e expressão de neurotrofinas (NGF E BDNF) e seus receptores no coração de modelo experimental da doença de Chagas
(Universidade Federal de Minas GeraisUFMG, 2017-02-23)
The present study evaluated ultrastructural alterations of autonomic varicosities and the expression of the neurotrophins NGF (Nerve Growth Factor) and BDNF (Brain Derived Neurotrophic Factor) in addition to their receptors, ...
An Agonistic mAb Directed to the TrkC Receptor Juxtamembrane Region Defines a Trophic Hot Spot and Interactions with p75 Coreceptors
(2010)
The D5 domain of TrkC receptors is a docking site for Neurotrophin-3 (NT-3), but other domains may be relevant for function or harmonizing signals with p75(NTR) coreceptors. We report a monoclonal antibody (mAb) 2B7 targeting ...
Reduced inflammatory state promotes reinnervation of endometriotic-like lesions in TNFRp55 deficient mice
(Oxford University Press, 2019-07)
Endometriosis is a chronic gynecological disease, characterized by growth of endometrial tissue in ectopic sites due to alteration of peritoneal homeostasis and deregulation of apoptosis. Here we have examined whether ...