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Diuretics prevent Rho-kinase activation and expression of profibrotic/oxidative genes in the hypertensive aortic wall
(2016)
Background:
Diuretics are current antihypertensive drugs since they reduce blood pressure and cardiovascular risk. Increased vascular tone is modulated in a relevant way by the RhoA/Rho-kinase (ROCK) pathway, by acting on ...
Serum amyloid A induces reactive oxygen species (ROS) production and proliferation of fibroblast
(WILEY-BLACKWELL PUBLISHING, INC, 2011)
Serum amyloid A (SAA) levels are elevated highly in acute phase response and elevated slightly and persistently in chronic diseases such as rheumatoid arthritis and diabetes. Given that fibroblasts exert profound effects ...
The possible role of a bacterial aspartate β-decarboxylase in the biosynthesis of alamandine
The understanding of the renin-angiotensin system (RAS) has significantly expanded over the last two decades.
The elucidation of angiotensin-converting enzyme 2 (ACE2) that converts angiotensin (Ang) II into Ang (1–7) ...
Insulin Reverses D-Glucose-Increased Nitric Oxide and Reactive Oxygen Species Generation in Human Umbilical Vein Endothelial Cells
(2015)
Vascular tone is controlled by the L-arginine/nitric oxide (NO) pathway, and NO bioavailability is strongly affected by hyperglycaemia-induced oxidative stress. Insulin leads to high expression and activity of human cationic ...
Cellular stress from excitatory neurotransmission contributes to cholesterol loss in hippocampal neurons aging in vitro
(Elsevier Inc, 2011-07)
After approximately 3 weeks in vitro, hippocampal neurons present many of the typical hallmarks accompanying neuronal aging in vivo, including accumulation of reactive oxygen species (ROS), lipofuscin granules, heterochromatic ...
Aerobic Exercise During Advance Stage of Uncontrolled Arterial Hypertension
(2021-06-03)
Aim: To evaluate the influence of physical training on myocardial function, oxidative stress, energy metabolism, and MAPKs and NF-κB signaling pathways in spontaneously hypertensive rats (SHR), at advanced stage of arterial ...
Hsp70 regulation on Nox4/p22phox and cytoskeletal integrity as an effect of losartan in vascular smooth muscle cells
(Springer, 2013-06)
A series of signaling cascades are activated after angiotensin II binds to angiotensin II type I receptor (AT1R), a peptide that is an important mediator of oxidative stress. Hsp70 regulates a diverse set of signaling ...
Antihypertensive effects of inducible nitric oxide synthase inhibition in experimental pre-eclampsia
(Wiley-blackwellHobokenEUA, 2013)
A fraction containing kaempferol-3,4′-dimethylether from Larrea divaricata Cav. induces macrophage activation on mice infected with Candida albicans
(Wiley, 2014-06)
Larrea divaricata Cav. is a plant growing in South America. Both the infusion and a derived fraction (F1) of L. divaricata have proved to have immunomodulatory properties. Moreover, F1 can activate macrophages obtained ...