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Sub-lethal levels of amyloid β-peptide oligomers decrease non-transferrin-bound iron uptake and do not potentiate iron toxicity in primary hippocampal neurons
(2012)
Two major lesions are pathological hallmarks in Alzheimer's disease (AD): the presence of neurofibrillary tangles formed by intracellular aggregates of the hyperphosphorylated form of the cytoskeletal tau protein, and of ...
APOE and Alzheimer’s Disease: Evidence Mounts that Targeting APOE4 may Combat Alzheimer’s Pathogenesis
(Humana Press Inc., 2019)
Comparação de placas e emanranhados na doença de Alzheimer através da histologia e imuno-histoquímica
(Universidade Federal de PernambucoUFPEBrasilPrograma de Pos Graduacao em Patologia, 2018)
Effect of the inflammation on the aggregation of the tau and amyloid-β polypeptides in the pyramidal neurons on the hippocampus of a triple transgenic murine model for the Alzheimer’s disease
(Instituto Tecnológico y de Estudios Superiores de Monterrey, 2020-11-18)
Alzheimer’s Disease (AD) is the most important form of dementia. It represents 70% of all dementia cases worldwide. On a molecular level, AD is characterized by the presence of two fibrillar lesions: the neurofibrillary ...
Inhibition of phospholipase A(2) in rat brain decreases the levels of total Tau protein
(SPRINGER WIEN, 2011)
The microtubule-associated protein Tau promotes the assembly and stability of microtubules in neuronal cells. Six Tau isoforms are expressed in adult human brain. All six isoforms become abnormally hyperphosphorylated and ...
Targeting Brain α7 Nicotinic Acetylcholine Receptors in Alzheimer's Disease: Rationale and Current Status.
(Springer, 2014-11)
Alzheimer’s disease (AD) is the most common form of dementia among older persons. Pathognomonic hallmarks of the disease include the development of amyloid senile plaques and deposits of neurofibrillary tangles. These ...
Targeting Brain alpha;7 Nicotinic Acetylcholine Receptors in Alzheimer's Disease: Rationale and Current Status.
(Adis Int Ltd, 2014-11)
Alzheimer´s disease (AD) is the most common form of dementia among older persons. Pathognomonic hallmarks of the disease include the development of amyloid senile plaques and deposits of neurofibrillary tangles. These ...
Hepcidin attenuates amyloid beta-induced inflamatory and pro-oxidant responses in astrocytes and microglia
(2017)
Alzheimer's disease (AD) is characterized by extracellular senile plaques, intracellular neurofibrillary tangles, and neuronal death. Aggregated amyloid-beta (A beta) induces inflammation and oxidative stress, which have ...
Mechanisms of tau self-aggregation and neurotoxicity
(2011)
Pathological tau protein aggregates can be found in brain of patients with some of the neurodegenerative diseases collectively known as tauopathies, which include Alzheimer's disease (AD). Since tau post-translational ...
Cien años de la enfermedad de Alzheimer. La inmunoterapia ¿una esperanza?
(2007)
In 1906 Alois Alzheimer, described the cerebral lesions
characteristic of the disorder that received his name: senile plaques and neurofibrillary tangles.
Alzheimer’s disease (AD) is now, 100 years after, the most prevalent ...