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Reelin activates the small GTPase TC10 and VAMP7 to promote neurite outgrowth and regeneration of dorsal root ganglia (DRG) neurons
(Wiley, 2021-01)
Axonal outgrowth is a fundamental process during the development of central (CNS) and peripheral (PNS) nervous system as well as in nerve regeneration and requires accurate axonal navigation and extension to the correct ...
Efeitos do FK-506 na regeneração de nervos após neurorrafia láteo-terminal: estudo em ratos
(Universidade Estadual Paulista (Unesp), 2014-02-04)
The latero-terminal neurorrhaphy without injury to the donor nerve, represented great advances in microsurgery of peripheral nerves. The receptor nerve distal stump was sutured on the lateral side of the donor nerve, without ...
Dynamics of degeneration and regeneration in developing zebrafish peripheral axons reveals a requirement for extrinsic cell types
(2012)
Background: Understanding the cellular mechanisms regulating axon degeneration and regeneration is crucial for developing treatments for nerve injury and neurodegenerative disease. In neurons, axon degeneration is distinct ...
Developmental changes of gene expression after spinal cord injury in neonatal opossums
(ELSEVIER SCIENCE BV, 2010)
Changes in gene expression have been measured 24 h after injury to mammalian spinal cords that can and cannot regenerate In opossums there is a critical period of development when regeneration stops being possible at 9 ...
Is there a window of opportunity for the therapeutic use of vitamin D in multiple sclerosis?
(2022-09-01)
Multiple sclerosis is an autoimmune treatable but not curable disease. There are a multiplicity of medications for multiple sclerosis therapy, including a class entitled disease-modifying drugs that are mainly indicated ...
Efeitos do FK-506 na regeneração de nervos após neurorrafia láteo-terminal: estudo em ratos
(Universidade Estadual Paulista (Unesp), 2015)
Activation of the unfolded protein response promotes axonal regeneration after peripheral nerve injury
(Nature Publishing Group, 2016)
Although protein-folding stress at the endoplasmic reticulum (ER) is emerging as a driver of neuronal dysfunction in models of spinal cord injury and neurodegeneration, the contribution of this pathway to peripheral nerve ...