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A "minimal" sodium channel construct consisting of ligated S5-P-S6 segments forms a toxin-activatable ionophore
(2002)
The large size (six membrane-spanning repeats in each of four domains) and asymmetric architecture of the voltage-dependent Na+ channel has hindered determination of its structure. With the goal of determining the minimum ...
Batrachotoxin-modified sodium channels from squid optic nerve in planar bilayers: Ion conduction and gating properties
(1989)
Squid optic nerve sodium channels were characterized in planar bilayers in the presence of batrachotoxin (BTX). The channel exhibits a conductance of 20 pS in symmetrical 200 mM NaCI and behaves as a sodium electrode. The ...
Cation permeability of a cloned rat epithelial amiloride-sensitive Na+ channel
(1997)
1. Conductance of heterotrimeric rat epithelial Na+ channels (α,β,γ-rENaCs) for Li+ and Na+ in planar lipid bilayers was a non-linear function of ion concentration, with a maximum of 30.4 ± 2.9 pS and 18.5 ± 1.9 pS at 1 M ...
Investigation of the relationship between the structure and function of Ts2, a neurotoxin from Tityus serrulatus venom
(WILEY-BLACKWELLMALDEN, 2012-04)
Scorpion toxins targeting voltage-gated sodium (NaV) channels are peptides that comprise 6076 amino acid residues cross-linked by four disulfide bridges. These toxins can be divided in two groups (a and beta toxins), ...
Sistema de multicanais: desafios enfrentados na migração da venda tradicional de varejo para o sistema omnichannel
(2018-06-23)
A integração de canais pode apresentar oportunidades e ameaças para as empresas podendo melhorar ou comprometer o desempenho. Tendo em vista os desafios dessa integração bem como o desenvolvimento de estratégias que atendam ...
Microcin E492 forms ion channels in phospholipid bilayer membranes
(1993)
Microcin E492, a polypeptide antibiotic, has been shown to have an Mr, of 6,000 by urea-SDS-polyacrylamide gel electrophoresis of the fluorescently labelled compound. It is known that the bactericidal action of microcin ...
Brain osmo-sodium sensitive channels and the onset of sodium appetite
(Academic Press Inc Elsevier Science, 2019-12)
The aim of the present study was to determine whether the TRPV1 channel is involved in the onset of sodium appetite. For this purpose, we used TRPV1-knockout mice to investigate sodium depletion-induced drinking at different ...
A Independência da Escolha dos Canais de Marketing nas Rendas dos Produtores Orgânicos Americanos2
(Sociedade Brasileira de Economia e Sociologia Rural, 2017)
One of the issues related to strategies for capturing value in organic production activities is the decision regarding the appropriate product distribution channel. The literature points out the importance of analyzing the ...