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P75 neurotrophin receptor-mediated apoptosis in sympathetic neurons involves a biphasic activation of jnk and up-regulation of tumor necrosis factor-alpha-converting enzyme/adam17
(AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, 2010)
Tetraspanin1 promotes NGF signaling by controlling TrkA receptor proteostasis
(Birkhauser Verlag Ag, 2019-09)
The molecular mechanisms that control the biosynthetic trafficking, surface delivery, and degradation of TrkA receptor are essential for proper nerve growth factor (NGF) function, and remain poorly understood. Here, we ...
The p75(NTR) neurotrophin receptor is required to organize the mature neuromuscular synapse by regulating synaptic vesicle availability
(2019)
The coordinated movement of organisms relies on efficient nerve-muscle communication at the neuromuscular junction. After peripheral nerve injury or neurodegeneration, motor neurons and Schwann cells increase the expression ...
New insights into the control of neurotrophic growth factor receptor signaling: Implications for nervous system development and repair
(Wiley Blackwell Publishing, Inc, 2012-12)
Neurotrophic growth factors control neuronal development by activating specific receptor tyrosine kinase positive signaling pathways, such as Ras-MAPK and PI3K-Akt cascades. Once activated, neurotrophic factor receptors ...
Progesterone treatment of spinal cord injury: effects on receptors, neurotrophins and myelination
(Humana Press, 2006-01)
In addition to its traditional role in reproduction, progesterone (PROG) has demonstrated neuroprotective and promyelinating effects in lesions of the peripheral and central nervous systems, including the spinal cord. The ...