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Metformin improves ovarian follicle dynamics by reducing theca cell proliferation and CYP-17 expression in an androgenized rat model
(BioMed Central, 2018)
Abstract
Background
Metformin influences insulin receptor signaling, which might interfere with the proliferation of ovarian follicular structures and steroidogenesis. We ...
Effect of metformin on markers of epithelial mesenchymal transition induced by TGF-beta in mammary cells
(Spandidos Publ Ltd, 2014)
Metformin: Repurposing Opportunities for Cognitive and Mood Dysfunction
(Bentham Science Publ Ltd, 2014-01-01)
Background: Cognitive deficits differentially affect individuals with type 2 diabetes mellitus (T2DM) and mood disorders. Accumulating evidence implicates disturbances in metabolism as salient to cognitive function. Thus, ...
Effect of metformin on markers of epithelial mesenchymal transition induced by TGF-beta in mammary cells
(Spandidos Publ Ltd, 2013-01-01)
Vitamin B12 deficiency associated with high doses od metformin in older people diabetic Déficit de vitamina B12 asociado con altas dosis de metformina en adultos mayores diabéticos
(Grupo Aula Medica S.A., 2014)
Introduction: The aim of the study was to estimate if B12 deficiency is associated with the use of metformin in the elderly diabetics. Methods: Case-control study in diabetic OP. Cases (n = 137) were defined as elderly ...
Metformin Reduces NGF-Induced Tumour Promoter Effects in Epithelial Ovarian Cancer Cells
(MDPI, 2020)
Epithelial ovarian cancer (EOC) is a lethal gynaecological neoplasm characterized by rapid growth and angiogenesis. Nerve growth factor (NGF) and its high affinity receptor tropomyosin receptor kinase A (TRKA) contribute ...
Metformin improves ovarian follicle dynamics by reducing theca cell proliferation and CYP-17 expression in an androgenized rat model
(Biomed Central Ltd, 2018)
Background: Metformin influences insulin receptor signaling, which might interfere with the proliferation of ovarian follicular structures and steroidogenesis. We hypothesize that reductions in glucose and insulin levels ...
Diabetic concentrations of metformin inhibit platelet-mediated ovarian cancer cell progression
(2017)
Clinical studies have suggested a survival benefit in ovarian cancer patients with type 2 diabetes mellitus taking metformin, however the mechanism by which diabetic concentrations of metformin could deliver this effect ...
Metformin reduces platelet-enhanced ovarian cancer cell EMT, sphere formation and migration
(2015)
The anti-diabetic drug Metformin has shown benefits not only in diabetic patients, but also in patients with endometriosis, polycystic ovary syndrome and ovarian cancer. Metformin use has demonstrated clinical correlation ...