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High glucose concentration stimulates intracellular renin activity and angiotensin II generation in rat mesangial cells
(Amer Physiological Soc, 2004-06-01)
Increased intrarenal renin-angiotensin system activity contributes to diabetic nephropathy. ANG II generation in mesangial cells (MC) is increased by high-glucose (HG) exposure. This study assessed the mechanisms involved ...
Estudo da expressão do receptor p2x7 e da síntese de óxido nítrico em célula mesangial imortalizada de camundongo em meio com alta glicose
(Universidade Federal de São Paulo (UNIFESP), 2016-06-30)
Diabetes mellitus (DM) is a non-transmissible chronic disease characterized by hyperglycemia, that injured many tissues as endothelium, leading to vascular disease and diabetic nephropathy (DN). Glomerular mesangial cells ...
Increased glomerular filtration rate and impaired contractile function of mesangial cells in TRPC6 knockout mice
(Nature Publishing Group, 2017-12)
The present study was conducted to determine if TRPC6 regulates glomerular filtration rate (GFR) and the contractile function of glomerular mesangial cells (MCs). GFR was assessed in conscious TRPC6 wild type and knockout ...
Adenosine mediates transforming growth factor-beta 1 release in kidney glomeruli of diabetic rats
(WILEY, 2009)
Up regulation of the transforming growth factor-beta 1 (TGF-beta 1) axis has been recognized as a pathogenic event for progression of glomerulosclerosis in diabetic nephropathy. We demonstrate that glomeruli isolated from ...
The IgA1 immune complex-mediated activation of the MAPK/ERK kinase pathway in mesangial cells is associated with glomerular damage in IgA nephropathy
(NATURE PUBLISHING GROUPNEW YORK, 2012)
IgA nephropathy (IgAN), the most common primary glomerulonephritis worldwide, has significant morbidity and mortality as 20-40% of patients progress to end-stage renal disease within 20 years of onset. In order to gain ...
Induction of proinflammatory cytokines and nitric oxide by Trypanosoma cruzi in renal cells
(Springer, 2011-08-01)
Chagas disease is typically associated with cardiac involvement. During the acute phase of murine infection with Trypanosoma cruzi, severe acute myocarditis can develop. Prior to cardiac alteration, however, infected mice ...
Identification of tyrosine hydroxylase and biopterin mediating mesangial cells production of catecholamines in culture.
(Williams & Wilkins, 1997-09-01)