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Structural changes induced by interactions between thyroid hormones and phospholipid membranes: a Raman Spectroscopy study
(Wiley, 2012-11)
Previous reports from our laboratory have shown that thyroid hormones induce changes in the fluidity and permeability of phospholipid bilayers and modify the transmembrane dipolar organization according to their iodine ...
Crystallographic and spectroscopic characterization of a molecular hinge: Conformational changes in bothropstoxin I, a dimeric Lys49 phospholipase A2 homologue
(Wiley-Blackwell, 1998-03-01)
Bothropstoxin I(BthTX-I) from the venom of Bothrops jararacussu is a myotoxic phospholipase A2 (PLA2) homologue which, although catalytically inactive due to an Asp49-->Lys substitution, disrupts the integrity of lipid ...
Preferential location of lidocaine and etidocaine in lecithin bilayers as determined by EPR, fluorescence and H-2 NMR
(Elsevier B.V., 2008-01-01)
We have examined the effect of the uncharged species of lidocaine (LDC) and etidocaine (EDC) on the acyl chain moiety of egg phosphatidylcholine liposomes. Changes in membrane organization caused by both anesthetics were ...
Crystallographic and spectroscopic characterization of a molecular hinge: Conformational changes in bothropstoxin I, a dimeric Lys49 phospholipase A2 homologue
(Wiley-Blackwell, 1998-03-01)
Bothropstoxin I(BthTX-I) from the venom of Bothrops jararacussu is a myotoxic phospholipase A2 (PLA2) homologue which, although catalytically inactive due to an Asp49-->Lys substitution, disrupts the integrity of lipid ...
Preferential location of lidocaine and etidocaine in lecithin bilayers as determined by EPR, fluorescence and H-2 NMR
(Elsevier B.V., 2008-01-01)
We have examined the effect of the uncharged species of lidocaine (LDC) and etidocaine (EDC) on the acyl chain moiety of egg phosphatidylcholine liposomes. Changes in membrane organization caused by both anesthetics were ...
Crystallographic and spectroscopic characterization of a molecular hinge: Conformational changes in Bothropstoxin I, a dimeric Lys49- phospholipase A2 homologue
(1998-03-01)
Bothropstoxin I (BthTX-I) from the venom of Bothrops jararacussu is a myotoxic phospholipase A2 (PLA2) homologue which, although catalytically inactive due to an Asp49→Lys substitution, disrupts the integrity of lipid ...
Combining nuclear magnetic resonance with molecular dynamics simulations to address sumatriptan interaction with model membranes
(Elsevier Ireland, 2019-12)
The goal of this work is to obtain a complete map on the interactions between sumatriptan, an amphiphilic ionizable anti-migraine drug, with lipid bilayers. To this end, we combined two physico-chemical techniques – nuclear ...
Flexible bacterial cellulose-based BC-SiO2-TiO2-Ag membranes with self-cleaning, photocatalytic, antibacterial and UV-shielding properties as a potential multifunctional material for combating infections and environmental applications
(2021-02-01)
This research study reports the formation of flexible and multifunctional organic-inorganic hybrid membranes (BC-SiO2-TiO2/Ag) based on bacterial cellulose (BC) that contain photoactive (TiO2) and antibacterial (Ag) ...
Correlation of [RuCl3(dppb)(VPy)] cytotoxicity with its effects on the cell membranes: an investigation using Langmuir monolayers as membrane models
(American Chemical Society - ACSWashington, 2014-09)
One of the major challenges in drug design is to identify compounds with potential toxicity toward target cells, preferably with molecular-level understanding of their mode of action. In this study, the antitumor property ...
Vibrational spectroscopy for probing molecular-level interactions in organic films mimicking biointerfaces
(Elsevier BVAmsterdam, 2014-05)
Investigation into nanostructured organic films has servedmany purposes, including the design of functionalized surfaces that may be applied in biomedical devices and tissue engineering and for studying physiological ...