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Long-Term Humoral and Cellular Immune Responses Elicited by a Heterologous Plasmodium vivax Apical Membrane Antigen 1 Protein Prime/Adenovirus Boost Immunization Protocol
(Amer Soc Microbiology, 2011-09-01)
Apical membrane antigen 1 (AMA-1) is an invasion-related Plasmodium antigen that is expressed during both intracellular and extracellular asexual stages of the parasite's life cycle, making it an ideal target for induction ...
Memory immune responses and protection of chickens against a nephropathogenic infectious bronchitis virus strain by combining live heterologous and inactivated homologous vaccines
(2019-01-01)
In this study, we evaluated antibody and cell-mediated immune (CMI) responses in the mucosal and systemic compartments and protection against challenge with a nephropathogenic Brazilian (BR-I) strain of infectious bronchitis ...
Viral Load and Cytokine Response Profile Does Not Support Antibody-Dependent Enhancement in Dengue-Primed Zika Virus-Infected Patients
(Oxford Univ Press Inc, 2017-10-15)
Background. The pathogenesis of severe dengue disease involves immune components as biomarkers. The mechanism by which some dengue virus (DENV)-infected individuals progress to severe disease is poorly understood. Most ...
Genetic Vaccination against Experimental Infection with Myotropic Parasite Strains of Trypanosoma cruzi
(Hindawi Publishing Corporation, 2014-01-01)
In earlier studies, we reported that a heterologous prime-boost regimen using recombinant plasmid DNA followed by replication-defective adenovirus vector, both containing Trypanosoma cruzi genes encoding trans-sialidase ...
Genetic vaccine for tuberculosis (pVAXhsp65) primes neonate mice for a strong immune response at the adult stage
(2007-11-29)
Background: Vaccination of neonates is generally difficult due to the immaturity of the immune system and consequent higher susceptibility to tolerance induction. Genetic immunization has been described as an alternative ...
Genetic vaccine for tuberculosis (pVAXhsp65) primes neonate mice for a strong immune response at the adult stage
(2007-11-29)
Background: Vaccination of neonates is generally difficult due to the immaturity of the immune system and consequent higher susceptibility to tolerance induction. Genetic immunization has been described as an alternative ...
Dengue Virus and Vaccines: How Can DNA Immunization Contribute to This Challenge?
(Frontiers Media, 2021)
Vacinação com a proteína 2 da superfície de amastigotas contra a infecção experimental pelo Trypanosoma cruzi: eficácia de diferentes estratégias vacinais e mecanismos de imunidade
(Universidade Federal de São Paulo (UNIFESP), 2009)
A imunização genética com um DNA plasmidial, contendo o gene que
codifica a proteína 2 da superfície de amastigotas (ASP-2), é capaz de proteger
parte dos camundongos altamente suscetíveis A/Sn contra uma infecção ...
The polymeric antigen BLSOmp31 confers protection against Brucella ovis infection in rams
(Elsevier, 2009-11)
We have engineered the polymeric vaccine BLSOmp31 by decorating the highly immunogenic and decameric Brucella lumazine synthase with an exposed loop of the Brucella outer membrane protein Omp31. In the present study, we ...
Desenvolvimento de um modelo de vacinação contra Toxoplasma Gondii utilizando Corynebacterium pseudotuberculosis atenuadas recombinantes como veículo para a apresentação de antígenos
(Universidade Federal de Minas GeraisBrasilICB - DEPARTAMENTO DE BIOLOGIA GERALPrograma de Pós-Graduação em GenéticaUFMG, 2012-09-30)
Toxoplasmosis is a worldwide disease and its etiologic agent is the protozoan intracellular parasite Toxoplasma gondii. The disease presents a clinical picture that varies from asymptomatic infections to extremely serious ...