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Flunitrazepam–Membrane Binding: A Sensor for Drug-Induced GABAA-R and Membrane Structure Changes
(Elsevier Academic Press Inc., 2016)
Flunitrazepam (FNZ) is a sedative–hypnotic benzodiazepine with important therapeutic usefulness and significant abuse liability. Its capability to induce anterograde amnesia favors FNZ use as a “date-rape drug” administered ...
Stereo-selective activity of menthol on GABA(A) receptor
(Wiley, 2009)
GABAA receptor plasticity in Jurkat T cells
(Elsevier France-editions Scientifiques Medicales Elsevier, 2013-12)
GABAA receptors (GABAAR) mediate inhibitory neurotransmission in the human brain. Neurons modify subunit expression, cellular distribution and function of GABAAR in response to different stimuli, a process named plasticity. ...
Gonadal hormone-independent sex differences in GABAA receptor activation in rat embryonic hypothalamic neurons
(Wiley Blackwell Publishing, Inc, 2020-03)
Background and Purpose: GABAA receptor functions are dependent on subunit composition, and, through their activation, GABA can exert trophic actions in immature neurons. Although several sex differences in GABA-mediated ...
Synthesis and GABAA receptor activity of a 6,19-oxido analogue of pregnanolone
(Pergamon-Elsevier Science Ltd, 2003-02)
3α-Hydroxy-6,19-oxidopregn-4-ene-20-one (4) was prepared in seven steps from pregnanolone acetate. At 0.1 μM concentration 4 significantly increased GABA induced 36Cl- influx in hamster cerebral cortex synaptoneurosomes ...
Respostas cardiovasculares e na ingestão de água e NaCl hipertônico em ratos com doença periodontal tratados com agonista GABAA no núcleo parabraquial lateral
(Universidade Estadual Paulista (UNESP), 2014)
Ontogenese das crises convulsivas induzidas por um agonista inverso dos receptores benzodiazepinicos em ratos: estudo comportamental, eletrografico e histopatologico
(Universidade Federal de São Paulo (UNIFESP), 1986)
Coupling between GABAA-R ligand-binding activity and membrane organization in β-cyclodextrin-treated synaptosomal membranes from bovine brain cortex: new insights from EPR experiments
(Humana Press, 2012-02)
Correlations between GABAA-receptor (GABAA-R) activity and molecular organization of synaptosomal membranes (SM) were studied along the protocol for cholesterol (Cho) extraction with b-cyclodextrin (b-CD). The mere ...
Structure and dynamics of neurosteroid binding to the α1β2γ2 GABAA receptor
(Pergamon-Elsevier Science Ltd, 2018-09-01)
Neurosteroids are the principal endogenous modulators of the γ-Aminobutyric acid receptors (GABAARs), pentameric membrane-bound proteins that can be assembled from at least 19 subunits. In the most abundant GABAAR arrangement ...
QSAR modeling of the interaction of flavonoids with GABA(A) receptor
(Elsevier France-editions Scientifiques Medicales Elsevier, 2008-08)
Experimentally assigned values to binding affinity constants of flavonoid ligands towards the benzodiazepine site of the GABA(A) receptor complex were compiled from several publications, and enabled to perform a predictive ...