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A bioinformatics tool for epitope-based vaccine design that accounts for human ethnic diversity : Application to emerging infectious diseases
(2015-03-03)
Background: Peptide vaccination based on multiple T-cell epitopes can be used to target well-defined ethnic populations. Because the response to T-cell epitopes is restricted by HLA proteins, the HLA specificity of T-cell ...
Prediction of Epitopes in the Proteome of Helicobacter pylori
(Canadian Center of Science and Education, 2018-06)
Helicobacter pylori (H. pylori) is classified by the World Health Organization (WHO) as a group I carcinogen and
is one of the most efficient human pathogens with over half of the world's population colonized by ...
Improved pan-specific MHC class I peptide-binding predictions using a novel representation of the MHC-binding cleft environment
(Wiley, 2014)
Major histocompatibility complex (MHC) molecules play a key role in cell-mediated immune responses presenting bounded peptides for recognition by the immune system cells. Several in silico Methods: have been developed to ...
Computational comparison of availability in CTL/gag epitopes among patients with acute and chronic HIV-1 infection
(Elsevier, 2018-06-27)
Background: Recent studies indicate that there is selection bias for transmission of viral polymorphisms associated with higher viral fitness. Furthermore, after transmission and before a specific immune response is mounted ...
Identification of Promiscuous T cell Epitopes on Mayaro virus structural proteins using immunoinformatics, molecular modeling, and QM:MM approaches
(Universidade Federal do Rio Grande do NorteBrasilUFRNFarmácia, 2021)
Putative virulence factors of Corynebacterium pseudotuberculosis FRC41: vaccine potential and protein expression
(Biomed Central Ltd, 2016-05-16)
Background: Corynebacterium pseudotuberculosis, a facultative intracellular bacterial pathogen, is the etiological agent of caseous lymphadenitis (CLA), an infectious disease that affects sheep and goats and it is responsible ...