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Extracellular cAMP activates molecular signalling pathways associated with sperm capacitation in bovines
(Oxford University Press, 2017-05)
STUDY QUESTION: Is extracellular cAMP involved in the regulation of signalling pathways in bovine sperm capacitation? SUMMARY ANSWER: Extracellular cAMP induces sperm capacitation through the activation of different ...
Nucleotide sequence of a 13-1,3-glucanase Isoenzyme II(A) gene of Oerskovia xanthineolytica LL G109 (Cellulomonas cellulans) and initial characterization of the recombinant enzyme expressed in Bacillus subtilis
(1996)
The nucleotide sequence of the βgIII(A) gene, encoding the extracellular β-1,3-glucanase II(A) (βgIII(A)) of the yeast-lytic actinomycete Oerskovia xanthineolytica LL G109, was determined. Sequence comparison shows that ...
Human erythrocytes release ATP by a novel pathway involving VDAC oligomerization independent of pannexin-1
(Springer Nature, 2018-12)
We previously demonstrated that the translocase protein TSPO2 together with the voltage-dependentanion channel (VDAC) and adenine nucleotide transporter (ANT) were involved in a membrane transportcomplex in human red blood ...
Caracterização enzimática da e-ntpdase em linfócitos residentes de orgãos imunes primários, secundários e não imunes de ratos wistar
(Universidade Federal de Santa MariaBrasilBioquímicaUFSMPrograma de Pós-Graduação em Ciências Biológicas: Bioquímica ToxicológicaCentro de Ciências Naturais e Exatas, 2021-09-03)
Ectoenzymes play an important role in controlling the signaling developed by adenine nucleotides and nucleosides in countless cells. However, little information is found in the scientific literature about the biochemical ...
Hidrolise de nucleotideos da adenina em pacientes com meningite asseptica e bacteriana
(Universidade Federal de Santa MariaBRBioquímicaUFSMPrograma de Pós-Graduação em Ciências Biológicas: Bioquímica Toxicológica, 2007-11-30)
The meningitis is a serious inflammatory illness of meninges, the membranes that recover and protect encephalo and the spinal cord. The main causing agents of the meningitis are the viruses and the bacteria. Some works ...
Conformational changes during the reaction cycle of Plasma Membrane Ca2+-ATPase in the autoinhibited and activated states
(Portland Press, 2021-05)
Plasma membrane Ca2+-ATPase (PMCA) transports Ca2+ by a reaction cycle including phosphorylated intermediates. Calmodulin binding to the C-terminal tail disrupts autoinhibitory interactions, activating the pump. To assess ...
Avaliação da sinalização purinérgica em plaquetas e linfócitos de pacientes com anemia falciforme
(Universidade Federal de Santa MariaBrasilFarmacologiaUFSMPrograma de Pós-Graduação em Ciências FarmacêuticasCentro de Ciências da Saúde, 2016-03-17)
Sickle cell anemia (SCA) is a hemoglobinopathy characterized by hemolysis and vaso-occlusions caused by rigidly distorted red blood cells, genetically determined by homozigous hemoglobin S (HbSS). The SCA is associated ...
ATP is released from autophagic vesicles to the extracellular space in a VAMP7-dependent manner
(Landes Bioscience, 2012-11)
Autophagy is a normal degradative pathway that involves the sequestration of cytoplasmic components and organelles in a vacuole called autophagosome. SNAREs proteins are key molecules of the vesicle fusion machinery. Our ...
Evaluation of the promotion of pro-metastatic capacities mediated by sEVs secreted by MDA-MB-231 metastatic breast cancer cells and identification of “EMT-promoter” sEV-miRs present in their cargo
(Universidad del Desarrollo. Facultad de Medicina, 2023)
Breast cancer (BC) is one of the most common and deathly cancers worldwide.
However, despite the improvements in screening and treatment, there is a high probability of local recurrence and distant metastasis to occur; the ...