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Ethanol reduces the endothelin-B receptor-mediated increase in portal inflow resistance in the isolated, perfused canine liver
(Lippincott Williams & WilkinsPhiladelphiaEUA, 1998)
Endothelin-2 differential expression in normal and early-stages of colon cancer development
(Scientific Research Publishing, 2013-07)
The endothelin family has been related with several pathological diseases including cardiovascular disorders, hypertension and cancer. However, little is known about endothelin system in early stages of colorectal cancer ...
Role of endothelin receptor type A on catecholamine regulation in the olfactory bulb of DOCA-salt hypertensive rats: Hemodynamic implications
(Elsevier Science, 2019-11)
Increasing evidence shows that the olfactory bulb is involved in blood pressure regulation in health and disease. Enhanced noradrenergic transmission in the olfactory bulb was reported in hypertension. Given that endothelins ...
Mechanisms involved in the long-term modulation of tyrosine hydroxylase by endothelins in the olfactory bulb of normotensive rats
(Elsevier, 2011-12)
The olfactory bulbs play a relevant role in the interaction between the animal and its environment. The existence of endothelin-1 and -3 in the rat olfactory bulbs suggests their role in the control of diverse functions ...
Involvement of endothelins in deoxycorticosterone acetate–salt hypertension through the modulation of noradrenergic transmission in the rat posterior hypothalamus
(Wiley, 2015-06)
What is the central question of this study? Does ex vivo administration of endothelin-1 and endothelin-3 regulate noradrenergic transmission in the posterior hypothalamus of deoxycorticosterone acetate–salt hypertensive ...
Endothelin-converting enzyme-1c promotes stem cell traits and aggressiveness in colorectal cancer cells
(Facultad de Medicina y CienciaCentro de Biología Celular y Biomedicina CEBICEM, 2020)
Endothelin-1 is a mitogenic peptide that activates several proliferation, survival, and invasiveness pathways. The effects of endothelin-1 rely on its activation by endothelin-converting enzyme-1 (ECE1), which is expressed ...
Plasmatic Biochemical Variables Associated with Polymorphisms in the Endothelin-1 and Endothelin-1 Receptor a Genes in Hypertensive Patients: Pilot Study
(Sciencedomain, 2016-01)
Endothelin-1 (ET-1) is a potent vasoconstrictive peptide, and its activity is mediated by thetype A receptor (EDNRA). This action may play a significant role in the etiology of hypertension.There are different works that ...
Safety and efficacy of sitaxsentan 50 and 100 mg in patients with pulmonary arterial hypertension
(ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTDLONDON, 2012)
Objective: To assess safety and efficacy of sitaxsentan 50 and 100 mg in patients with pulmonary arterial hypertension (PAH). Background: Sitaxsentan is a highly selective endothelin-A receptor antagonist that was recently ...