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Insights on the inhibition properties of Jatromollistatin (a cyclic heptapeptide) against Crotalus adamanteus metalloendopeptidase using molecular docking analysis
(2022-01-01)
Jatropha mollissima is endemic to Brazil and is used for traditional medicinal purposes, including the treatment of snakebite. In this study, latex obtained from this plant was fractioned using reversed-phase chromatography, ...
Targeting tumors using peptides
(Multidisciplinary Digital Publishing Institute, 2020-02)
To penetrate solid tumors, low molecular weight (Mw < 10 KDa) compounds have an edge over antibodies: their higher penetration because of their small size. Because of the dense stroma and high interstitial fluid pressure ...
A peptide derived from alpha-fetoproteln inhibits the proliferation induced by estradiol in mammary tumor cells in culture
(2008)
This study was aimed to obtain additional information on the activity of a cyclized 9-amino acid peptide (cP) containing the active site of alpha fetoprotein, which inhibits the estrogen-stimulated proliferation of tumor ...
Design of a Helical-Stabilized, Cyclic, and Nontoxic Analogue of the Peptide Cm-p5 with Improved Antifungal Activity
(2019-11-19)
Following the information obtained by a rational design study, a cyclic and helical-stabilized analogue of the peptide Cm-p5 was synthetized. The cyclic monomer showed an increased activity in vitro against Candida albicans ...
Influence of lipopolysaccharide outer-core in the intrinsic resistance to antimicrobial peptides and virulence in edwardsiella ictaluri.
(2016)
The genus Edwardsiella consists of bacteria with an intrinsic resistance to cyclic cationic antimicrobial peptides (CAMPs). Edwardsiella ictaluri, a pathogen of the catfish (Ictalurus punctatus) and the causative agent of ...
Interface Immobilization Chemistry of c RGD-based Peptides Regulates Integrin Mediated Cell Adhesion
(Wiley, 2014-03)
The interaction of specifi c surface receptors of the integrin family with different extracellular matrix-based ligands is of utmost importance for the cellular adhesion process. A ligand consists of an integrin-binding ...
A novel melanoma-targeting peptide screened by phage display exhibits antitumor activity
(Springer, 2010-12-01)
Peptide display on the phage surface has been widely used to identify specific peptides targeting several in vivo and in vitro tumor cells and the tumor vasculature, playing a role in the discovery of bioactive antitumor ...