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An appetitive experience after fear memory destabilization attenuates fear retention: Involvement GluN2B-NMDA receptors in the basolateral amygdala complex
(Cold Spring Harbor Laboratory Press, 2016-09)
It is known that a consolidated memory can return to a labile state and become transiently malleable following reactivation. This instability is followed by a restabilization phase termed reconsolidation. In this work, we ...
Fear-context association during memory retrieval requires input from granular to dysgranular retrosplenial cortex
(Academic Press Inc Elsevier Science, 2019-09)
The contribution of the granular (area 29, A29) and dysgranular (area 30, A30) subdivisions of the retrosplenial cortex (RSC) to contextual fear memory (CFM) retrieval remains elusive. Here, intact and orchiectomized (ORC) ...
LIMK, Cofilin 1 and actin dynamics involvement in fear memory processing
(Academic Press Inc Elsevier Science, 2020-07-11)
Long-term memory has been associated with morphological changes in the brain, which in turn tightly correlate with changes in synaptic efficacy. Such plasticity is proposed to rely on dendritic spines as a neuronal canvas ...
Heterozygous Che-1 KO mice show deficiencies in object recognition memory persistence
(Elsevier Ireland, 2016-10)
Transcriptional regulation is a key process in the formation of long-term memories. Che-1 is a protein involved in the regulation of gene transcription that has recently been proved to bind the transcription factor NF-κB, ...
Effects of nociceptin/orphanin FQ in the acquisition of contextual and tone fear conditioning in rats
(Amer Psychological Assoc, 2008-02-01)
Nociceptin, or orphanin FQ (N/OFQ), the endogenous ligand of NOP receptors, is known to regulate learning and memory processes. To verify the role of N/OFQ in the acquisition of contextual (CFC) and tone fear conditioning ...
Memory impairment induced by IL-1beta is reversed by alpha-MSH through central melanocortin-4 receptors
(Academic Press Inc Elsevier Science, 2009-12)
Interleukin-1beta (IL-1beta) significantly influences memory consolidation. Treatments that raise the level of IL-1beta in the brain, given after training, impair contextual fear conditioning. The melanocortin alpha-MSH ...
Intranasal Cotinine Plus Krill Oil Facilitates Fear Extinction, Decreases Depressive-Like Behavior, and Increases Hippocampal Calcineurin A Levels in Mice
(2018-10-01)
Failure in fear extinction is one of the more troublesome characteristics of posttraumatic stress disorder (PTSD). Cotinine facilitates fear memory extinction and reduces depressive-like behavior when administered 24 h ...
Efeito da valência do estímulo social na persistência da memória contextual
(Universidade Federal de Minas GeraisBrasilICB - INSTITUTO DE CIÊNCIAS BIOLOGICASPrograma de Pós-Graduação em Ciências Biológicas - Fisiologia e FarmacologiaUFMG, 2018-05-25)
The neurobiological bases of contextual memories come from paradigms involving negative stimuli, such as shock. However, memories of the same context can represent positive experiences, not just negative experiences. So, ...