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Modificaciones post traduccionales de CDK5 y sus efectos en la viabilidad neuronal
(Universisdad de Chile, 2009)
La quinasa dependientes de ciclina 5 (Cdk5) esta involucrada en proceso de migración, crecimiento neurótico y diferenciación neuronal. La actividad de Cdk5 en el sistema nervioso esta regulado por la interacción con sus ...
Participación De P35, Activador Neuroespecífico De CDK5, En La Muerte Celular Inducida Por El Péptido Beta Amieloide. Aspectos Celulares Y MolecularesParticipation Of P35, Neurospecific Activator Of CDK5, In Celular Death Induced By Amyeloid BetaParticipación de p35, activador neuroespecífico de cdk5, en la muerte celular inducida por el péptido beta amieloide. Aspectos celulares y molecularesparticipatión of p35, neurospecific activator of cdk5, in celular death induced by amyeloid beta
(2006)
La enfermedad de Alzheimer (EA) es un desorden neurodegenerativo que se caracteriza por dos tipos de agregados proteicos: extracelulares (placas seniles) e intracelulares (ovillos neurofibrilares, ONF). Los ONF están ...
Tau Phosphorylation by cdk5 and Fyn in Response to Amyloid Peptide A beta(25-35): Involvement of Lipid Rafts
(IOS PRESS, 2009)
Alzheimer’s disease (AD) is characterized by the accumulation of protein filaments, namely extracellular amyloid-β
(Aβ) fibrils and intracellular neurofibrillary tangles, which are composed of aggregated hyperphosphorylated ...
Genetic Background and Climatic Droplet Keratopathy Incidence in a Mapuche Population from Argentina
(Public Library Science, 2013-09)
Purpose To determine whether the incidence of and susceptibility to climatic droplet keratopathy (CDK), an acquired, often bilateral degenerative corneal disease, is influenced by the genetic background of the individuals ...
The protein kinase cdk5: Structural aspects, roles in neurogenesis and involvement in Alzheimer's pathology
(2001)
A set of different protein kinases have been involved in tau phosphorylations, including glycogen synthase kinase 3b (GSK3b), MARK kinase, MAP kinase, the cyclin-dependent kinase 5 (Cdk5) system and others. The latter ...
Cdk5 downregulation enhances synaptic plasticity
(2017)
CDK5 is a serine/threonine kinase that is involved in the normal function of the adult brain and plays a role in neurotransmission and synaptic plasticity. However, its over-regulation has been associated with Tau ...
Cdk5 regulates Rap1 activity
(2013)
Rap1 signaling is important for migration, differentiation, axonal growth, and during neuronal polarity. Rap1 can be activated by external stimuli, which in turn regulates specific guanine nucleotide exchange factors such ...
CDK5 downregulation enhances synaptic plasticity
(2016)
CDK5 is a serine/threonine kinase that is involved in the normal function of the adult brain and plays a role in neurotransmission and synaptic plasticity. However, its over-regulation has been associated with Tau ...