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Dermcidin exerts its oncogenic effects in breast cancer via modulation of ERBB signaling
(Biomed Central Ltd, 2015-02-19)
Background: We previously identified dermicidin (DCD), which encodes a growth and survival factor, as a gene amplified and overexpressed in a subset of breast tumors. Patients with DCD-positive breast cancer have worse ...
Down-modulation of erbB2 activity is necessary but not enough in the differentiation of 3T3-L1 preadipocytes
(Wiley, 2008-05)
The high incidence of obesity-related pathologies, led to the study of the mechanisms involved in preadipose cell proliferation and differentiation. Here, we demonstrate that modulation of erbB2, plays a fundamental ...
Cooverexpression Of Erbb1 And Erbb4 Receptors Predicts Poor Clinical Outcome In Pn+ Oral Squamous Cell Carcinoma With Extranodal Spread
(Springer Science and Business Media Netherlands, 2014)
Neuregulin 1-erbB signaling is necessary for normal myelination and sensory function.
(Society for Neuroscience, 2006-12)
To investigate the role of erbB signaling in the interactions between peripheral axons and myelinating Schwann cells, we generated transgenic mice expressing a dominant-negative erbB receptor in these glial cells. Mutant ...
MiR-16 mediates trastuzumab and lapatinib response in ErbB-2-positive breast and gastric cancer via its novel targets CCNJ and FUBP1
(Nature Publishing Group, 2016-03)
ErbB-2 amplification/overexpression accounts for an aggressive breast cancer (BC) subtype (ErbB-2-positive). Enhanced ErbB-2expression was also found in gastric cancer (GC) and has been correlated with poor clinical outcome. ...
Alterations of the CCND1 and HER-2/neu (ERBB2) proteins in esophageal and gastric cancers
(Elsevier B.V., 2006-02-01)
We evaluated the relationship of amplification and polysomy of both the CCND1 and the ERBB2 (alias HER-2/NEU) genes to the overexpression of their proteins in esophageal and gastric cancers and also their association with ...
Alterations of the CCND1 and HER-2/neu (ERBB2) proteins in esophageal and gastric cancers
(Elsevier B.V., 2006-02-01)
We evaluated the relationship of amplification and polysomy of both the CCND1 and the ERBB2 (alias HER-2/NEU) genes to the overexpression of their proteins in esophageal and gastric cancers and also their association with ...