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Parabens inhibit hNaV 1.2 channels
(Elsevier Masson, 2020-08)
Propylparaben, a commonly used antimicrobial preservative, has been reported as an anticonvulsant agent targeting neuronal Na+ channels (NaV). However, the specific features of the NaV channel inhibition by this agent have ...
Lipase Catalyzed Synthesis of Alkyl Phenylacetates with Anticonvulsant Activity
(Colegio de Farmacéuticos de la Provincia de Buenos Aires, 2020-06)
. A pesar del amplio espectro de medicamentos antiepilépticos disponibles, un tercio de los pacientes todavía sufren de epilepsia resistente a los mismos, lo que justifica la búsqueda continua de nuevas terapias. La actividad ...
Efeito do ácido rosmarínico sobre as crises epilépticas e alterações comportamentais em diferentes modelos experimentais de epilepsia
(Universidade Federal de Santa MariaBrasilFarmacologiaUFSMPrograma de Pós-Graduação em FarmacologiaCentro de Ciências da Saúde, 2016-03-01)
Epilepsy is a chronic neurological disease characterized by recurrent seizures. Current anticonvulsant
drugs are ineffective in nearly one third of patients and may cause significant adverse effects.
Rosmarinic acid is ...
A anticonvulsive fraction from Scaptocosa raptoria (Araneae : Lycosidae) spider venom
(Elsevier B.V., 2004-11-23)
Several spider neurotoxins are known to show highly selective effects on nervous tissues. Intracerebral injection into rats of spider venom from Scaptocosa raptoria, prevents seizures induced by convulsant agents. Injection ...
Determination of anticonvulsants in human plasma using SPME in a heated interface coupled online to liquid chromatography (SPME-LC)
(2012)
A simple and sensitive method using solid phase microextraction (SPME) and liquid chromatography (LC) with heated online desorption (SPME-LC) was developed and validated to analyze anticonvulsants (AEDs) in human plasma ...
Anticonvulsant profile of 2-ethylthio-7-methyl-4-(4-methylphenyl) pyrazolo[1,5-a][1,3,5]triazine
(Universidade de Sao Paulo, 2014-03)
This work evaluates the central nervous effects in ICR strain mice of 2-ethylthio-7-methyl-4-(4-methylphenyl)pyrazolo[1,5-a][1,3,5]triazine (MH4b1), a compound obtained by an efficient one-step reaction of S,S-diethyl ...